Figure 1

Frequency of copy number alterations. Microsatellite stable tumours with dissemination (stage II-III with distant recurrence, stage IV) and without (stage II-III no recurrence). Frequency difference is shown with a darker colour. Different types of CNAs were analysed separately: A) Gain (to >2 copies). B) Relative gain (to >25% above individual sample average copy number). C) Loss (to <2 copies). D) Relative loss (to <67% of individual sample average). E) Loss-of-heterozygosity (no minor allele copy). Regions with significant difference in alteration frequency (p < 0.05, Fisher’s exact test) are marked by black bars below each panel.