Table 4 Toxicities
From: The off-label use of targeted therapies in sarcomas: the OUTC’S program
Total* | GRADE** | ||||
|---|---|---|---|---|---|
N (%) | 1 N (%) | 2 N (%) | 3 N (%) | 4 N (%) | |
SORAFENIB (n = 116) | |||||
At least 1 toxicity reported | 94 (81) | ─ | ─ | ─ | ─ |
Intestinal toxicity | 63 (54) | 26 (22) | 27 (23) | 13 (11) | 0 (0) |
Skin toxicity, infections | 56 (49) | 26 (22) | 20 (18) | 12 (10) | 0 (0) |
Hematologic toxicity | 18 (16) | 5 (4) | 10 (9) | 5 (4) | 0 (0) |
Neurologic toxicity | 12 (10) | 9 (3) | 2 (2) | 1 (1) | 0 (0) |
Cardiologic toxicity | 10 (9) | 4 (3) | 4 (3) | 2 (2) | 0 (0) |
Pulmonary toxicity | 4 (3) | 2 (2) | 1 (1) | 1 (1) | 0 (0) |
Renal toxicity | 1 (1) | 0 (0) | 1 (1) | 0 (0) | 0 (0) |
Other toxicities | 67 (58) | 19 (16) | 34 (29) | 19 (16) | 1 (1) |
SUNITINIB (n = 66) | |||||
At least 1 toxicity reported | 49 (74) | ─ | ─ | ─ | ─ |
Intestinal toxicity | 26 (39) | 16 (24) | 7 (11) | 5 (8) | 0 (0) |
Hematologic toxicity | 21 (32) | 5 (8) | 11 (17) | 3 (5) | 4 (6) |
Skin toxicity, infections | 12 (18) | 6 (9) | 6 (9) | 1 (2) | 0 (0) |
Neurologic toxicity | 6 (9) | 2 (3) | 1 (2) | 2 (3) | 1 (2) |
Pulmonary toxicity | 5 (8) | 3 (5) | 1 (2) | 1 (2) | 0 (0) |
Cardiologic toxicity | 3 (5) | 3 (5) | 0 (0) | 0 (0) | 0 (0) |
Renal toxicity | 1 (2) | 0 (0) | 0 (0) | 0 (0) | 1 (2) |
Other toxicities | 38 (58) | 15 (23) | 14 (21) | 13 (20) | 2 (3) |
IMATINIB (n = 23) | |||||
At least 1 toxicity reported | 20 (87) | ─ | ─ | ─ | ─ |
Intestinal toxicity | 12 (52) | 6 (26) | 4 (17) | 1 (4) | 1 (4) |
Hematologic toxicity | 6 (26) | 2 (9) | 2 (9) | 2 (9) | 0 (0) |
Skin toxicity, infections | 2 (9) | 2 (9) | 0 (0) | 0 (0) | 0 (0) |
Neurologic toxicity | 1 (4) | 0 (0) | 1 (4) | 1 (4) | 0 (0) |
Pulmonary toxicity | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Cardiologic toxicity | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Renal toxicity | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Other toxicities | 17 (74) | 4 (17) | 12 (52) | 3 (13) | 0 (0) |
SIROLIMUS + CYCLOPHOSPHAMIDE (n = 18) | |||||
At least 1 toxicity reported | 9 (50) | ─ | ─ | ─ | ─ |
Intestinal toxicity | 5 (28) | 4 (22) | 1 (6) | 0 (0) | 0 (0) |
Hematologic toxicity | 3 (17) | 1 (6) | 1 (6) | 0 (0) | 1 (6) |
Pulmonary toxicity | 2 (11) | 1 (6) | 0 (0) | 0 (0) | 1 (6) |
Skin toxicity, infections | 1 (6) | 1 (6) | 0 (0) | 0 (0) | 0 (0) |
Neurologic toxicity | 1 (6) | 0 (0) | 1 (6) | 0 (0) | 0 (0) |
Renal toxicity | 1 (6) | 0 (0) | 0 (0) | 1 (6) | 0 (0) |
Cardiologic toxicity | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
Other toxicities | 7 (39) | 3 (17) | 4 (22) | 0 (0) | 0 (0) |