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Figure 5 | BMC Cancer

Figure 5

From: MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

Figure 5

Forced PTEN expression in SK-BR-3/R cells restored trastuzumab sensitivity. A. PTEN expression were retrived and p-Akt was decreased in SK-BR-3/R cells transfected with GFP-PTEN; B. MTT assay indicated that ectopic PTEN expression in SK-BR-3/R cells reduced cell viability in the absence of trastuzumab. When trastuzumab was added, cell viability was further inhibited (*P < 0.05); C. TUNEL assay suggested that ectopic expression of PTEN resensitized the trastuzumab-treated SK-BR-3/R cells to apoptosis (*P < 0.05).

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