Figure 1

MTDH expression in HER2 positive breast cancer patients was associated with PTEN reduction and trastuzumab resistance. A. Representative image of MTDH immunohistochemical staining in paraffin-embedded tissue from118 breast cancer patients (IRS =0, 3, 6, 12, magnification at 400×, scale bar =100 μm); B. The comparison of PFS between patients with high MTDH expression or low MTDH expression. Median PFS was 6 months in patients with high MTDH expression and 15 months with low MTDH expression. Log Rank test P = 0.024; Patients were treated with trastuzumab-based first line therapy; C. Different clinical benefit (CB) rates in two subgroups, high MTDH expression (n =22) and low MTDH expression (n =14) were found (P =0.025); D. MTDH level was negatively correlated with PTEN expression in patients treated with trastuzumab-based first line therapy; E. The scatter plot of MTDH and PTEN expressions in patients with different clinical benefits; F. The regression analysis of MTDH and PTEN expressions.