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Table 3 Univariate and multivariate Cox proportional hazards analysis for overall survival (stage l-lV) (N = 155)

From: Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer

Variables Categories Univariate analysis Multivariate analysis
   HR (95% CI) P value HR (95% CI) P value
Depth (T factor) T1, T2 vs. T3, T4 1.78 (0.95-3.53) NS   
Lymph node status Positive vs. negative 5.32 (2.75-10.32) <0.001 6.27 (2.94-13.36) <0.001
Heregulin expression Positive vs. negative 2.22 (1.23-4.01) 0.008 1.81 (0.94-3.46) NS
EGFR expression Positive vs. negative 2.31 (1.25-4.27) 0.007 0.45 (0.16-1.27) NS
pEGFR expression Positive vs. negative 3.93 (2.19-7.05) <0.001 2.85 (1.05-7.73) 0.04
ErbB2 expression Positive vs. negative 1.95 (1.08-3.51) 0.027 0.59 (0.16-2.15) NS
pErbB2 expression Positive vs. negative 2.29 (1.23-4.24) 0.008 1.78 (0.47-6.72) NS
ErbB2 expression Positive vs. negative 2.33 (1.30-4.18) 0.005 1.75 (0.87-3.53) NS
pErbB3 expression Positive vs. negative 2.46 (1.37-4.41) 0.003 1.12 (0.53-2.38) NS
ErbB4 expression Positive vs. negative 2.99 (1.67-5.37) <0.001 1.42 (0.55-3.65) NS
pErbB4 expression Positive vs. negative 3.84 (2.11-6.99) <0.001 2.59 (1.01-6.69) 0.049