Table 3 Univariate and multivariate Cox proportional hazards analysis for overall survival (stage l-lV) (N = 155)
From: Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer
Variables | Categories | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Â | Â | HR (95% CI) | P value | HR (95% CI) | P value |
Depth (T factor) | T1, T2 vs. T3, T4 | 1.78 (0.95-3.53) | NS | Â | Â |
Lymph node status | Positive vs. negative | 5.32 (2.75-10.32) | <0.001 | 6.27 (2.94-13.36) | <0.001 |
Heregulin expression | Positive vs. negative | 2.22 (1.23-4.01) | 0.008 | 1.81 (0.94-3.46) | NS |
EGFR expression | Positive vs. negative | 2.31 (1.25-4.27) | 0.007 | 0.45 (0.16-1.27) | NS |
pEGFR expression | Positive vs. negative | 3.93 (2.19-7.05) | <0.001 | 2.85 (1.05-7.73) | 0.04 |
ErbB2 expression | Positive vs. negative | 1.95 (1.08-3.51) | 0.027 | 0.59 (0.16-2.15) | NS |
pErbB2 expression | Positive vs. negative | 2.29 (1.23-4.24) | 0.008 | 1.78 (0.47-6.72) | NS |
ErbB2 expression | Positive vs. negative | 2.33 (1.30-4.18) | 0.005 | 1.75 (0.87-3.53) | NS |
pErbB3 expression | Positive vs. negative | 2.46 (1.37-4.41) | 0.003 | 1.12 (0.53-2.38) | NS |
ErbB4 expression | Positive vs. negative | 2.99 (1.67-5.37) | <0.001 | 1.42 (0.55-3.65) | NS |
pErbB4 expression | Positive vs. negative | 3.84 (2.11-6.99) | <0.001 | 2.59 (1.01-6.69) | 0.049 |