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Table 1 Relationship between heregulin, ErbB1-4, pErbB1-4 and clinicopathological factors

From: Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer

   Heregulin EGFR pEGFR ErbB2 pErbB2 ErbB3 pErbB3 ErbB4 pErbB4
  No. No. (percent) P value No. (percent) P value No. (percent) P value No. (percent) P value No. (percent) P value No. (percent) P value No. (percent) P value No. (percent) P value No. (percent) P value
Age                    
 <66 78 38 (49) NS 46 (59) NS 27 (35) NS 14 (18) 0.018 12 (15) NS 28 (36) NS 19 (24) NS 17 (22) NS 9 (12) NS
 ≥66 77 33 (43)   33 (43)   23 (30)   27 (35)   18 (23)   36 (47)   21 (27)   16 (21)   16 (21)  
Gender                    
 Male 90 41 (46) NS 45 (50) NS 26 (29) NS 27 (30) NS 20 (22) NS 41 (46) NS 22 (24) NS 17 (19) NS 16 (18) NS
 Female 65 30 (46)   34 (52)   24 (37)   14 (22)   10 (15)   23 (35)   18 (28)   16 (25)   9 (4)  
Site                    
 Colon 106 45 (42) NS 52 (49) NS 34 (32) NS 29 (27) NS 20 (19) NS 40 (38) NS 25 (24) NS 23 (22) NS 19 (18) NS
 Rectum 49 26 (53)   27 (55)   16 (33)   12 (24)   10 (20)   24 (49)   15 (31)   10 (20)   6 (12)  
Depth                    
 pT1 12 4 (33) 0.03 4 (33) 0.004 0 0.003 1 (8) NS 0 0.015 1 (8) 0.003 0 0.015 0 0.004 0 0.009
 pT2 29 8 (28)   7 (24)   4 (14)   5 (17)   5 (17)   6 (21)   4 (14)   1 (3)   0  
 pT3 105 52 (50)   62 (59)   42 (40)   30 (29)   20 (19)   52 (50)   35 (33)   31 (30)   24 (23)  
 pT4 9 7 (78)   6 (67)   4 (44)   5 (56)   5 (56)   5 (56)   1 (11)   1 (11)   1 (11)  
Lymphatic invasion                    
 Negative 31 9 (29) 0.044 11 (35) NS 8 (26) NS 7 (23) NS 4 (13) NS 12 (39) NS 8 (26) NS 3 (10) NS 3 (10) NS
 Positive 124 62 (50)   68 (55)   42 (39)   34 (27)   26 (21)   52 (42)   32 (26)   30 (24)   22 (18)  
Vascular invasion                    
 Negative 61 24 (39) NS 25 (41) 0.05 12 (20) 0.008 15 (25) NS 10 (16) NS 19 (31) 0.046 8 (13) 0.005 10 (16) NS 7 (11) NS
 Positive 94 47 (50)   54 (57)   38 (40)   26 (28)   20 (21)   45 (48)   32 (34)   23 (24)   18 (19)  
Lymph node status                    
 pN0 85 37 (44) NS 35 (41) 0.01 18 (21) 0.002 18 (21) NS 11 (13) 0.04 34 (40) NS 18 (21) NS 18 (21) NS 15 (18) NS
 pNx 70 34 (49)   44 (63)   32 (46)   23 (33)   19 (27)   30 (43)   22 (31)   15 (21)   10 (14)  
TNM stage                    
 I 35 11 (31) 0.023 9 (26) <0.001 3 (9) <0.001 5 (14) 0.033 4 (11) 0.031 7 (20) 0.026 3 (8) 0.041 1 (3) <0.001 0 0.005
 II 43 21 (49)   20 (47)   11 (26)   9 (21)   4 (9)   21 (49)   11 (26)   13 (30)   11 (26)  
 III 53 22 (42)   31 (58)   20 (38)   16 (31)   14 (26)   23 (43)   17 (32)   8 (15)   7 (13)  
 IV 24 17 (71)   19 (79)   16 (67)   11 (46)   8 (33)   13 (54)   9 (38)   11 (46)   7 (29)  
Liver metastatis                    
 Negative 133 55 (41) 0.001 62 (47) 0.01 35 (26) <0.001 30 (23) 0.016 22 (17) 0.041 52 (39) NS 32 (24) NS 22 (17) 0.001 18 (14) NS
 Positive 22 16 (73)   17 (77)   15 (68)   11 (50)   8 (36)   12 (55)   8 (36)   11 (50)   7 (32)  
Recurrence                    
 Negative 119 51 (43) NS 55 (46) 0.037 29 (24) <0.001 28 (24) NS 19 (16) NS 40 (34) 0.001 21 (18) <0.001 18 (15) 0.002 12 (10) 0.001
 Positive 36 20 (56)   24 (67)   21 (58)   13 (36)   11 (31)   24 (67)   19 (53)   15 (42)   13 (36)