Figure 2

Immunohistochemical localization of heregulin (A), EGFR (B), pEGFR (C), ErbB2 (D), pErbB2 (E-G), ErbB3 (H), pErbB3 (I), ErbB4 (J), and pErbB4 (K) in colorectal adenocarcinoma. A, Heregulin was stained in the cytoplasm of adenocarcinoma cells. 40x B, EGFR was stained in the cell membrane and cytoplasm of adenocarcinoma cells. 20x, Insert; EGFR in the cell membrane. 60x C, pEGFR was stained in the nucleus of adenocarcinoma cells. 20x, Insert; pEGFR in the cell membrane and cytoplasm. 60x D, ErbB2 was stained in the cell membrane of adenocarcinoma cells. 40x E, pErbB2 was stained in the cytoplasm of adenocarcinoma cells. 40x F, pErbB2 was stained in the cell membrane of adenocarcinoma cells. 40x G, pErbB2 was stained in the nucleus of adenocarcinoma cells. 40x H, ErbB3 was stained in the cell membrane and cytoplasm of adenocarcinoma cells. 20x, Insert; ErbB3 in the cell membrane. 60x I, pErbB3 was stained in the nucleus of adenocarcinoma cells. 40x J, ErbB4 was stained in the cell membrane of adenocarcinoma cells. 40x K, pErbB4 was stained in the cell membrane of adenocarcinoma cells. 40x.