Histological analyses of Kras, Hedgehog, and Wnt signaling components. (A) Pancreata was harvested and analyzed from 15-week old wild type (WT), p48Cre;LSL-Kras
G12D (KC), and p48Cre;LSL-Kras
DNMAML-GFP/+ (KC;DNMAML) mice. H&E staining at a high magnification (40×) compare the pancreatic histology in WT, KC, KC;DNMAML mice. Tissues were stained for downstream targets of Kras signaling (p-AKT and p-ERK), Hedgehog ligand (Shh), and downstream Wnt component (Beta-catenin). (B) Analysis of 26-week old mice.