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Table 4 Summary of Multi-factor Dimensionality (MDR) results

From: Oxidative stress in susceptibility to breast cancer: study in Spanish population

Model

Training accuracy

Testing accuracy

OR(95%CI)

p-value

CVC*

X2

0.5215

0.5093

1.18 (0.93-1.51)

0.1797

8/10

X2 – X5

0.5319

0.5199

1.30 (1.01-1.66)

0.041

8/10

X2 – X5 – X6

0.5353

0.5210

1.82 (1.28-2.58)

0.0007

7/10

X2 – X3 – X5 – X6

0.5371

0.5267

1.75 (1.26-2.44)

0.0008

10/ 10

  1. The polymorphisms rs406113, rs974334, rs1052133 and rs2284659 showing the highest statistical significance in the combinatorial set1 + set 2 were chosen for gene-gene interaction analysis. *CVC, cross-validation consistency. Testing accuracy, p-value and CVC significant were highlighted in bold.
  2. X2 = rs406113 (GPX6), X3 = rs974334 (GPX6), X5 = rs1052133 (OGG1), X6 = rs2284659 (SOD3).