Table 3 Genotype frequencies of relevant polymorphisms in different Sets

GCLC rs3736729

Set 1

Recessive

0.74 (0.54-1.01)

C/C

147 (22.4%)

79 (16.9%)

0.058

1458.7

A/A-A/C

508 (77.6%)

387 (83.1%)

Set 2

Recessive

0.89 (0.67-1.19)

C/C

191 (23.9%)

89 (21.8%)

0.43

1549.3

A/A-A/C

610 (76.2%)

319 (78.2%)

Set 1 + 2

Recessive

0.85 (0.73-1.00)

C/C

343 (23.1%)

177 (19.7%)

0.054

3160.5

A/A-A/C

1141 (76.9%)

723 (80.3%)

GPX6 rs406113

Set 1

Dominant

1.26 (0.98-1.62)

A/C-C/C

314 (51%)

272 (57.6%)

0.066

1408.9

A/A

302 (49%)

200 (42.4%)

Set 2

Dominant

1.18 (0.93-1.50)

A/C-C/C

435 (54.2%)

241 (58.4%)

0.17

1559.7

A/A

367 (45.8%)

172 (41.6%)

Set 1 + 2

Dominant

1.23 (1.04- 1.46)

A/C-C/C

759 (52.7%)

524 (57.8%)

0.015

3127.7

A/A

681 (47.3%)

382 (42.2%)

GPX6 rs974334

Set 1

Recessive

2.01 (1.07- 3.80)

G/G

18 (2.8%)

25 (5.4%)

0.03

1452.9

C/C-C/G

633 (97.2%)

441 (94.6%)

Set 2

Recessive

1.45 (0.70-3.01)

G/G

17 (2.1%)

13 (3%)

0.33

1592.6

C/C-C/G

785 (97.9%)

415 (97%)

Set 1 + 2

Recessive

1.73 (1.09 -2.73)

G/G

37 (2.5%)

39 (4.2%)

0.02

3194.7

C/C-C/G

1444 (97.5%)

881 (95.8%)

M6PR rs1805754

Set 1

Dominant

1.31 (1.02 -1.68)

A/C-C/C

257 (40%)

215 (46.1%)

0.034

1444.2

A/A

386 (60%)

251 (53.9%)

Set 2

Dominant

1.05 (0.83-1.34)

A/C-C/C

347 (44.1%)

191 (45.4%)

0.67

1565.8

A/A

440 (55.9%)

230 (54.6%)

Set 1 + 2

Dominant

1.15 (0.98-1.36)

A/C-C/C

619 (42.5%)

420 (46%)

0.093

3160.7

A/A

838 (57.5%)

493 (54%)

OGG1 rs1052133

Set 1

Recessive

1.76 (1.00-3.10)

G/G

34 (5.1%)

28 (8.1%)

0.051

1124

C/C-C/G

631 (94.9%)

319 (91.9%)

Set 2

Recessive

1.84 (1.11- 3.07)

G/G

33 (4.1%)

30 (7.3%)

0.02

1543.7

C/C-C/G

767 (95.9%)

378 (92.7%)

Set 1 + 2

Recessive

1.82 (1.31- 2.52)

G/G

64 (4.5%)

56 (7.9%)

4e -04

2665.8

C/C-C/G

1348 (95.5%)

655 (92.1%)

SOD3 rs2284659

Set 1

Recessive

1.30 (0.92-1.84)

T/T

83 (12.9%)

80 (17.2%)

0.14

1445.6

G/G-G/T

560 (87.1%)

386 (82.8%)

Set 2

Recessive

1.25 (0.90-1.73)

T/T

109 (13.6%)

69 (16.4%)

0.19

1577

G/G-G/T

693 (86.4%)

352 (83.6%)

Set 1 + 2

Recessive

1.33 (1.05- 1.67)

T/T

194 (13.2%)

153 (16.8%)

0.017

3172.3

G/G-G/T

1278 (86.8%)

760 (83.2%)

TXN rs2301241

Set 1

Dominant

0.80 (0.60-1.07)

C/T-C/C

460 (74.4%)

348 (71.2%)

0.14

1350.5

T/T

158 (25.6%)

141 (28.8%)

Set 2

Dominant

1.35 (1.03-1.78

C/T-C/C

569 (71.2%)

318 (77%)

0.03

1554.4

T/T

230 (28.8%)

95 (23%)

Set 1 + 2

Dominant

1.05 (0.87-1.27)

C/T-C/C

1014 (72.9%)

660 (73.9%)

0.59

3060.6

T/T

377 (27.1%)

233 (26.1%)

TXN rs4135179

Set 1

Dominant

1.27 (0.97-1.66)

A/G-G/G

178 (28%)

151 (32.8%)

0.085

1431

A/A

458 (72%)

310 (67.2%)

Set 2

Dominant

1.08 (0.83-1.39)

A/G-G/G

248 (31%)

136 (32.5%)

0.57

1571.2

A/A

553 (69%)

282 (67.5%)

Set 1 + 2

Dominant

1.14 (0.95-1.36)

A/G-G/G

435 (29.7%)

294 (32.5%)

0.16

3153

A/A

1029 (70.3%)

611 (67.5%)

TXN rs4135225

Set 1

Recessive

0.66 (0.45-0.96)

C/C

104 (16.2%)

48 (10.5%)

0.029

1431.1

T/T-C/T

536 (83.8%)

410 (89.5%)

Set 2

Recessive

0.97 (0.68-1.38)

C/C

104 (13%)

53 (12.7%)

0.87

1574.5

T/T-C/T

698 (87%)

366 (87.3%)

Set 1 + 2

Recessive

0.77 (0.60- 0.99)

C/C

212 (14.4%)

104 (11.5%)

0.041

3151.7

T/T-C/T

1257 (85.6%)

799 (88.5%)

XDH rs207454

Set 1

Recessive

4.98 (1.28- 19.34)

C/C

3 (0.5%)

9 (1.9%)

0.012

1450.3

A/A-A/C

646 (99.5%)

457 (98.1%)

Set 2

Recessive

1.61 (0.54-4.83)

C/C

7 (0.9%)

6 (1.4%)

0.4

1589.1

A/A-A/C

793 (99.1%)

421 (98.6%)

Set 1 + 2

Recessive

2.12 (1.11-4.04)

C/C

11 (0.8%)

15 (1.6%)

0.024

3188.5

A/A-A/C

1464 (99.2%)

904 (98.4%)