Table 7 The relationship between the CTCAE grading of xerostomia and the scores of the individual EORTC QLQ-C30 scales and the effect size of the differences
From: Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma
CTCAE grading of xerostomia | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Grade 0 (n = 77) | Grade 1 (n = 100) | Grade 2 (n = 133) | Grade 3 (n = 2) | ||||||||
Mean (SD) | Mean (SD) | Cohen’s D | ES | Mean (SD) | Cohen’s D | ES | Mean (SD) | Cohen’s D | ES | p | |
Global quality of life | 77 (12) | 63 (18) | 0.97 | M | 51 (22) | 1.48 | L | 42 (12) | 2.94 | L | <0.001 |
Physical functioning | 98 (5) | 91 (11) | 0.79 | M | 83 (19) | 1.10 | L | 70 (5) | 5.76 | L | <0.001 |
Role functioning | 95 (13) | 95 (11) | 0.02 | S | 84 (23) | 0.58 | M | 67 (0) | 3.21 | L | <0.001 |
Emotional functioning | 82 (15) | 86 (15) | 0.28 | S | 73 (18) | 0.57 | M | 50 (24) | 1.63 | L | <0.001 |
Cognitive functioning | 83 (17) | 83 (17) | 0.02 | S | 73 (19) | 0.59 | M | 50 (24) | 1.63 | L | <0.001 |
Social functioning | 95 (13) | 87 (17) | 0.52 | M | 72 (25) | 1.20 | L | 50 (24) | 2.39 | L | <0.001 |
Fatigue | 11 (16) | 19 (186) | 0.49 | M | 34 (22) | 1.18 | L | 56 (16) | 2.83 | L | <0.001 |
Nausea/Vomiting | 2 (5) | 3 (7) | 0.51 | M | 10 (15) | 0.77 | M | 33 (0) | 2.65 | L | <0.001 |
Pain | 5 (13) | 9 (15) | 0.33 | S | 26 (23) | 1.14 | L | 50 (24) | 2.39 | L | <0.001 |
Dyspnoea | 10 (16) | 8 (14) | 0.12 | S | 16 (21) | 0.34 | S | 33 (0) | 2.08 | L | 0.008 |
Insomnia | 29 (30) | 18 (21) | 0.42 | M | 30 (27) | 0.03 | S | 50 (24) | 0.79 | M | 0.002 |
Appetite loss | 5 (13) | 7 (14) | 0.19 | S | 17 (23) | 0.64 | M | 83 (24) | 4.16 | L | <0.001 |
Constipation | 14 (18) | 14 (20) | 0.12 | S | 19 (25) | 0.23 | S | 83 (24) | 3.31 | L | 0.032 |
Diarrhoea | 5 (13) | 7 (15) | 0.19 | S | 13 (18) | 0.54 | M | 50 (24) | 2.39 | L | 0.003 |
Financial problems | 5 (13) | 17 (24) | 0.65 | M | 28 (30) | 1.03 | L | 50 (24) | 2.39 | L | 0.002 |