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Table 7 The relationship between the CTCAE grading of xerostomia and the scores of the individual EORTC QLQ-C30 scales and the effect size of the differences

From: Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma

  CTCAE grading of xerostomia  
  Grade 0 (n = 77) Grade 1 (n = 100) Grade 2 (n = 133) Grade 3 (n = 2)  
  Mean (SD) Mean (SD) Cohen’s D ES Mean (SD) Cohen’s D ES Mean (SD) Cohen’s D ES p
Global quality of life 77 (12) 63 (18) 0.97 M 51 (22) 1.48 L 42 (12) 2.94 L <0.001
Physical functioning 98 (5) 91 (11) 0.79 M 83 (19) 1.10 L 70 (5) 5.76 L <0.001
Role functioning 95 (13) 95 (11) 0.02 S 84 (23) 0.58 M 67 (0) 3.21 L <0.001
Emotional functioning 82 (15) 86 (15) 0.28 S 73 (18) 0.57 M 50 (24) 1.63 L <0.001
Cognitive functioning 83 (17) 83 (17) 0.02 S 73 (19) 0.59 M 50 (24) 1.63 L <0.001
Social functioning 95 (13) 87 (17) 0.52 M 72 (25) 1.20 L 50 (24) 2.39 L <0.001
Fatigue 11 (16) 19 (186) 0.49 M 34 (22) 1.18 L 56 (16) 2.83 L <0.001
Nausea/Vomiting 2 (5) 3 (7) 0.51 M 10 (15) 0.77 M 33 (0) 2.65 L <0.001
Pain 5 (13) 9 (15) 0.33 S 26 (23) 1.14 L 50 (24) 2.39 L <0.001
Dyspnoea 10 (16) 8 (14) 0.12 S 16 (21) 0.34 S 33 (0) 2.08 L 0.008
Insomnia 29 (30) 18 (21) 0.42 M 30 (27) 0.03 S 50 (24) 0.79 M 0.002
Appetite loss 5 (13) 7 (14) 0.19 S 17 (23) 0.64 M 83 (24) 4.16 L <0.001
Constipation 14 (18) 14 (20) 0.12 S 19 (25) 0.23 S 83 (24) 3.31 L 0.032
Diarrhoea 5 (13) 7 (15) 0.19 S 13 (18) 0.54 M 50 (24) 2.39 L 0.003
Financial problems 5 (13) 17 (24) 0.65 M 28 (30) 1.03 L 50 (24) 2.39 L 0.002
  1. Abbreviations: CTCAE: Common Terminology Criteria for Adverse Events, v4.0; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30; SD: standard deviation; Cohen’s D was calculated relative to grade 0; ES: effect size based on Cohen’s D; S: small; M: moderate; L: large.