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Table 6 The relationship between the CTCAE grading of hearing loss and the scores of the individual EORTC QLQ-C30 scales and the effect size of the differences

From: Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma

  CTCAE grading of hearing loss  
  Grade 0 (n = 87) Grade 1 (n = 32) Grade 2 (n = 73) Grade 3-4 (n = 50)  
  Mean (SD) Mean (SD) Cohen’s D ES Mean (SD) Cohen’s D ES Mean (SD) Cohen’s D ES p
Global quality of life 62 (20) 58 (18) 0.20 S 54 (21) 0.68 M 49 (21) 0.94 L <0.001
Physical functioning 91 (13) 91 (13) 0.04 S 86 (18) 0.55 M 77 (19) 0.92 L <0.001
Role functioning 92 (19) 92 (15) 0.02 S 90 (18) 0.52 M 81 (22) 0.84 L <0.001
Emotional functioning 84 (18) 78 (19) 0.33 S 77 (19) 0.47 M 73 (17) 0.64 M 0.005
Cognitive functioning 82 (17) 77 (19) 0.28 S 77 (17) 0.60 M 70 (22) 0.81 L <0.001
Social functioning 85 (21) 82 (23) 0.13 S 77 (21) 0.43 M 69 (25) 0.70 M <0.001
Fatigue 22 (19) 21 (18) 0.04 S 31 (23) 0.46 M 35 (22) 0.67 M <0.001
Nausea/Vomiting 2 (7) 7 (13) 0.51 M 8 (14) 0.53 M 8 (16) 0.48 M 0.007
Pain 15 (22) 13 (17) 0.11 S 22 (24) 0.32 S 25(19) 0.53 M 0.007
Dyspnoea 8 (14) 14 (17) 0.38 S 16 (23) 0.47 M 14 (19) 0.39 S 0.022
Insomnia 21 (25) 21 (26) 0.01 S 29 (27) 0.33 S 28 (24) 0.30 S NS
Appetite loss 8 (14) 11 (16) 0.25 S 16 (22) 0.44 M 19 (29) 0.51 M 0.009
Constipation 16 (20) 11 (16) 0.27 S 17 (24) 0.03 S 24 (31) 0.20 S NS
Diarrhoea 9 (16) 11 (18) 0.13 S 13 (17) 0.26 S 24 (31) 0.21 S NS
Financial problems 19 (27) 21 (25) 0.08 S 22 (23) 0.14 S 12 (19) 0.49 M 0.020
  1. Abbreviations: CTCAE: Common Terminology Criteria for Adverse Events, v4.0; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30; SD: standard deviation; Cohen’s D was calculated relative to grade 0; ES: effect size based on Cohen’s D; S: small; M: moderate; L: large; NS: not significant.