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Table 4 The GLM-MANOVA model of the effects of the CTCAE scales on the fifteen EORTC QLQ-C30 scales

From: Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma

EORTC QLQ-C30
  One-factor model* Multifactor model**
Variable Wilk’s λ P value Wilk’s λ P value
Clinical variable     
 Age (40 v 41–60 v >60) 0.844 0.177 0.878 NS
 Gender (Male v Female) 0.891 0.048 0.881 NS
 Education years (6 yrs v 6-12 yrs v >12 yrs) 0.779 0.004 0.766 0.003
 Marital status (Without v with partner) 0.922 0.285 -- --
 AJCC stage (I v II v III v IV) 0.765 0.088 0.876 NS
 Radiotherapy technique (Non-IMRT v IMRT) 0.806 <0.001 0.739 0.002
 Chemotherapy (No v Yes) 0.894 0.058 0.957 NS
 Survival years (5 ~ 7 yrs v 7-10 yrs v >10 yrs) 0.795 0.012 0.795 0.021
CTCAE     
 Neuropathy (0 v 1 v 2 v 3) 0.650 <0.001 0.686 0.001
 Hearing loss (0 v 1 v 2 v 3 + 4) 0.658 <0.001 0.713 0.02
 Dysphagia (0 v 1 v 2 v 3) 0.702 0.002 0.755 NS
 Xerostomia (0 v 1 v 2 v 3) 0.631 <0.001 0.697 0.003
 Neck (0 v 1 v 2 + 3) 0.782 0.006 0.853 NS
  1. GLM-MANOVA: general linear model multivariate analysis of variance; EORTC QLQ-C30: European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30; CTCAE: Common Terminology Criteria for Adverse Events, v4.0; AJCC: American Joint of Cancer Committee published in 2002; IMRT: intensity modulated radiotherapy; NS: not significant; *The one factor model: only one independent variable was entered into the model; **The multifactor model: variables with p < 0.25 in one-factor model were entered as independent variables in the model (Backward exclusion).