Table 4 Cells with copy number variations (CNVs) of chromosomes 3, 7, and 17 and at 9p21 in urines from 1,575 tumor-free men
CNV | Locus | 0 | 1 | 2 | 3 | 4 | ≥5 | Total | Loss (CNV <2) | Gain (CNV >2) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Total | CEP 3 | N (%) | 130 (0.1) | 260 (0.1) | 186508 (98.7) | 549 (0.3) | 1313 (0.7) | 151 (0.1) | 188911 (100) | 390 (0.2) | 2013 (1.1) |
CEP 7 | N (%) | 5 (0) | 327 (0.2) | 186430 (98.7) | 702 (0.4) | 1317 (0.7) | 130 (0.1) | 188911 (100) | 332 (0.2) | 2149 (1.1) | |
CEP 17 | N (%) | 114 (0.1) | 907 (0.5) | 186242 (98.6) | 657 (0.3) | 904 (0.5) | 87 (0.0) | 188911 (100) | 1021 (0.5) | 1648 (0.9) | |
LSI 9p21 | N (%) | 736 (0.4) | 1089 (0.6) | 185417 (98.2) | 431 (0.2) | 1156 (0.6) | 82 (0.0) | 188911 (100) | 1825 (1.0) | 1669 (0.9) | |
Age (years) a | |||||||||||
<50 | CEP 3 | N (%) | 32 (0.1) | 62 (0.1) | 47873 (98.9) | 136 (0.3) | 251 (0.5) | 29 (0.1) | 48383 (100) | 94 (0.2) | 416 (0.9) |
CEP 7 | N (%) | 1 (0.0) | 80 (0.2) | 47861 (98.9) | 151 (0.3) | 257 (0.5) | 33 (0.1) | 48383 (100) | 81 (0.2) | 441 (0.9) | |
CEP 17 | N (%) | 15 (0.0) | 192 (0.4) | 47854 (98.9) | 137 (0.3) | 167 (0.3) | 18 (0.0) | 48383 (100) | 207 (0.4) | 322 (0.7) | |
LSI 9p21 | N (%) | 162 (0.3) | 230 (0.5) | 47638 (98.5) | 77 (0.2) | 248 (0.5) | 28 (0.1) | 48383 (100) | 392 (0.8) | 353 (0.7) | |
≥50 | CEP 3 | N (%) | 98 (0.1) | 198 (0.1) | 138635 (98.7) | 413 (0.3) | 1062 (0.8) | 122 (0.1) | 140528 (100) | 296 (0.2) | 1597 (1.1) |
CEP 7 | N (%) | 4 (0.0) | 247 (0.2) | 138569 (98.6) | 551 (0.4) | 1060 (0.8) | 97 (0.1) | 140528 (100) | 251 (0.2) | 1708 (1.2) | |
CEP 17 | N (%) | 99 (0.1) | 715 (0.5) | 138388 (98.5) | 520 (0.4) | 737 (0.5) | 69 (0.0) | 140528 (100) | 814 (0.6) | 1326 (0.9) | |
LSI 9p21 | N (%) | 574 (0.4) | 859 (0.6) | 137779 (98.0) | 354 (0.3) | 908 (0.6) | 54 (0.0) | 140528 (100) | 1433 (1.0) | 1316 (0.9) | |
Smoking | |||||||||||
Never | CEP 3 | N (%) | 37 (0.1) | 91 (0.2) | 51871 (98.8) | 140 (0.3) | 320 (0.6) | 33 (0.1) | 52492 (100) | 128 (0.2) | 493 (0.9) |
CEP 7 | N (%) | 1 (0.0) | 92 (0.2) | 51865 (98.8) | 198 (0.4) | 312 (0.6) | 24 (0.0) | 52492 (100) | 93 (0.2) | 534 (1.0) | |
CEP 17 | N (%) | 31 (0.1) | 258 (0.5) | 51808 (98.7) | 147 (0.3) | 230 (0.4) | 18 (0.0) | 52492 (100) | 289 (0.6) | 395 (0.8) | |
LSI 9p21 | N (%) | 199 (0.4) | 307 (0.6) | 51556 (98.2) | 106 (0.2) | 302 (0.6) | 22 (0.0) | 52492 (100) | 506 (1.0) | 430 (0.8) | |
Ever | CEP 3 | N (%) | 93 (0.1) | 169 (0.1) | 134637 (98.7) | 409 (0.3) | 993 (0.7) | 118 (0.1) | 136419 (100) | 262 (0.2) | 1520 (1.1) |
CEP 7 | N (%) | 4 (0.0) | 235 (0.2) | 134565 (98.6) | 504 (0.4) | 1005 (0.7) | 106 (0.1) | 136419 (100) | 239 (0.2) | 1615 (1.2) | |
CEP 17 | N (%) | 83 (0.1) | 649 (0.5) | 134434 (98.5) | 510 (0.4) | 674 (0.5) | 69 (0.1) | 136419 (100) | 732 (0.5) | 1253 (0.9) | |
LSI 9p21 | N (%) | 537 (0.4) | 782 (0.6) | 133861 (98.1) | 325 (0.2) | 854 (0.6) | 60 (0.0) | 136419 (100) | 1319 (1.0) | 1239 (0.9) | |
Creatinine (g/L) a | |||||||||||
<0.5 | CEP 3 | N (%) | 25 (0.1) | 42 (0.2) | 24377 (98.0) | 129 (0.5) | 254 (1.0) | 39 (0.2) | 24866 (100) | 67 (0.3) | 422 (1.7) |
CEP 7 | N (%) | 1 (0.0) | 43 (0.2) | 24361 (98.0) | 142 (0.6) | 273 (1.1) | 46 (0.2) | 24866 (100) | 44 (0.2) | 461 (1.9) | |
CEP 17 | N (%) | 21 (0.1) | 159 (0.6) | 24361 (98.0) | 142 (0.6) | 155 (0.6) | 28 (0.1) | 24866 (100) | 180 (0.7) | 325 (1.3) | |
LSI 9p21 | N (%) | 135 (0.5) | 166 (0.7) | 24205 (97.3) | 88 (0.4) | 248 (1.0) | 24 (0.1) | 24866 (100) | 301 (1.2) | 360 (1.4) | |
≥0.5 | CEP 3 | N (%) | 56 (0.0) | 166 (0.1) | 134228 (98.9) | 356 (0.3) | 865 (0.6) | 78 (0.1) | 135749 (100) | 222 (0.2) | 1299 (1.0) |
CEP 7 | N (%) | 4 (0.0) | 227 (0.2) | 134144 (98.8) | 439 (0.3) | 864 (0.6) | 71 (0.1) | 135749 (100) | 231 (0.2) | 1374 (1.0) | |
CEP 17 | N (%) | 60 (0.0) | 572 (0.4) | 134036 (98.7) | 424 (0.3) | 614 (0.5) | 43 (0.0) | 135749 (100) | 632 (0.5) | 1081 (0.8) | |
LSI 9p21 | N (%) | 456 (0.3) | 708 (0.5) | 133478 (98.3) | 285 (0.2) | 770 (0.6) | 52 (0.0) | 135749 (100) | 1164 (0.9) | 1107 (0.8) | |