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Table 3 Associations between MUC1 or VEGF mRNA positivity and clinicopathologic factors

From: Expressions of MUC1 and vascular endothelial growth factor mRNA in blood are biomarkers for predicting efficacy of gefitinib treatment in non-small cell lung cancer

 

MUC1 mRNA

VEGF mRNA

B0

B4w

B0

B4w

Positivity (n = 50)

Negativity (n = 16)

Positivity (n = 30

Negativity (n = 36)

Positivity (n = 47)

Negativity (n = 19)

Positivity (n = 29)

Negativity (n = 37)

Sex

        

 Male

27

10

16

21

25

12

17

20

 Female

23

6

14

15

22

7

12

17

P value

0.579

 

0.804

 

0.586

 

0.805

 

Smoking history

        

 Never

15

7

7

15

13

9

7

15

 Non-never

35

9

23

21

34

10

22

22

P value

0.225

 

0.121

 

0.156

 

0.168

 

Histology

        

 ADC

26

13

13

26

24

15

12

27

 Non-ADC

24

3

17

10

23

4

17

10

P value

0.045

 

0.024

 

0.053

 

0.013

 

Performance status

        

 0-1

40

12

22

30

36

16

22

30

 2-3

10

4

8

6

11

3

7

7

P value

0.730

 

0.375

 

0.741

 

0.763

 

Disease stage

        

 IIIB

7

3

6

4

5

5

6

4

 IV

43

13

24

32

42

14

23

33

P value

0.695

 

0.814

 

0.248

 

0.437

 

EGFR status

        

 Wild-type

32

6

21

17

31

7

21

17

 Mutation

13

9

6

16

12

10

7

15

 Unknown

5

1

3

3

4

2

1

5

P value

0.083

 

0.102

 

0.058

 

0.095

 

Tumor response

        

 PR

14

11

7

18

13

12

8

17

 SD

17

3

7

13

16

4

6

14

 PD

19

2

16

5

18

3

15

6

P value

0.013

 

0.002

 

0.025

 

0.018

 
  1. ADC, adenocarcinoma; PR, partial response; SD, stable disease; PD, progression disease.
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