Table 2 EC50 values in the LHRH receptor expressing HCC1806 and MDA-MB-231 cells and in LHRH-receptor negative LTK (-) cells subsequent to coincubation with AEZS-125 with and without pretreatment with 100 μM triptorelin
10-minute pretreatment | 10-minute treatment | EC50 of AEZS-125 (nM) | ||
|---|---|---|---|---|
LTK (-) | HCC1806 | MDA-MB-231 | ||
1% DMSO solvent control | AEZS-125 | 1070.0 ± 351.1 | 238.1 ± 194.6 | 392.0 ± 136.6 |
(n = 3) | (n = 3) | (n = 4) | ||
100 μM Triptorelin | AEZS-125 | 613.8 ± 217.4 | 282.7 ± 151.2 | 499.0 ± 140.1 |
(n = 3) | (n = 3) | (n = 4) | ||