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Table 4 Multivariate analysis of prognostic factors for LRFS, LNMFS, DMFS, RFS, and OS

From: Impact of preoperative anemia on relapse and survival in breast cancer patients

 

LRFS

LNMFS

DMFS

RFS

OS

     
 

HR (95% CI)

P

HR (95% CI)

P

95% CI

P

95% CI

P

95% CI

P

T stage

          

    T1

Ref

 

NS

NS

Ref

 

Ref

 

Ref

 

    T2

1.045 (0.532–2.050)

0.899

NS

NS

1.333 (0.962–1.847)

0.084

1.287 (0.976–1.697)

0.074

1.291 (0.925–1.803)

0.134

    ≥T3

2.676 (1.267–5.653)

0.010

NS

NS

1.983 (1.347–2.920)

0.001

2.021 (1.455–2.807)

<0.001

2.020 (1.371–2.975)

<0.001

N stage

          

    N0

Ref

 

Ref

 

Ref

 

Ref

 

Ref

 

    N1

2.601 (1.366–4.963)

0.004

2.235 (1.366–3.657)

0.001

2.040 (1.493–2.788)

<0.001

2.009 (1.544–2.615)

<0.001

1.942 (1.404–2.687)

<0.001

    N2

2.708 (1.122–6.534)

0.027

3.742 (2.058–6.805)

<0.001

3.484 (2.358–5.147)

<0.001

3.016 (2.152–4.225)

<0.001

4.200 (2.854–6.181)

<0.001

    N3

2.450 (0.859–6.989)

0.094

2.045 (0.912–4.487)

0.083

4.822 (3.175–7.323)

<0.001

3.856 (2.672–5.565)

<0.001

5.083 (3.307–7.812)

<0.001

    ER

          

    Negative

Ref

 

NS

NS

Ref

 

Ref

 

Ref

 

    Positive

0.525 (0.261–1.057)

0.071

NS

NS

0.670 (0.479–0.937)

0.019

0.726 (0.547–0.965)

0.027

0.845 (0.598–1.194)

0.340

    Strongly positive

0.340 (0.144–0.803)

0.014

NS

NS

0.804 (0.537–1.206)

0.292

0.757 (0.534–1.074)

0.119

0.566 (0.360–0.890)

0.014

PR

          

    Negative

Ref

 

NS

NS

NS

NS

Ref

NS

NS

NS

    Positive

1.709 (0.826–3.535)

0.149

NS

NS

NS

NS

1.409 (1.066–1.861)

0.016

NS

NS

    Strongly positive

2.989 (1.236–7.228)

0.015

NS

NS

NS

NS

0.899 (0.611–1.322)

0.588

NS

NS

HER-2

          

    Negative

Ref

 

NS

NS

NS

NS

NS

NS

NS

NS

    Positive

2.179 (1.232–3.855)

0.007

NS

NS

NS

NS

NS

NS

NS

NS

    Strongly positive

0.651 (0.292–1.451)

0.294

NS

NS

NS

NS

NS

NS

NS

NS

Hormonal therapy

NS

NS

0.537 (0.335–0.859)

0.009

NS

NS

0.733 (0.575–0.933)

0.012

0.682 (0.503–0.926)

0.014

Anemia

4.939 (2.875–8.484)

<0.001

5.160 (3.428–7.767)

<0.001

3.192 (2.489–4.094)

<0.001

4.104 (3.310–5.089)

<0.001

2.849 (2.205–3.680)

<0.001

  1. Abbreviations: LRFS local relapse-free survival, LNMFS lymph node metastasis-free survival, DMFS distant metastasis-free survival, RFS relapse-free survival, OS overall survival, ER estrogen receptor, PR progesterone receptor, HER-2 Human Epidermal Growth Factor Receptor-2, HR hazard ration, CI confidence interval, Ref: Reference group; NS: No significance.
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BMC Cancer

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