Elevated 14,15- epoxyeicosatrienoic acid by increasing of cytochrome P450 2C8, 2C9 and 2J2 and decreasing of soluble epoxide hydrolase associated with aggressiveness of human breast cancer

Table 1 EET-related gene expression in noncancerous tissue and adjacent breast cancer tissue

EET-related genes	Non-cancerous tissue	Breast cancer tissue, no. of samples (%)			P value*
EET-related genes	Non-cancerous tissue	-	+	++	P value*
CYP2C8	-	28 (70%)	4 (10%)	4 (10%)	0.019
	+	0	0	2 (5%)
	++	0	0	2 (5%)
CYP2C9	-	12 (30%)	6 (15%)	4 (10%)	0.094
	+	4 (10%)	2 (5%)	6 (15%)
	++	0	2 (5%)	4 (10%)
CYP2J2	-	28 (70%)	6 (15%)	2 (5%)	0.019
	+	0	0	2 (5%)
	++	0	0	2 (5%)
sEH	-	10 (25%)	6 (15%)	0	0.034
	+	6 (15%)	2 (5%)	4 (10%)
	++	8 (20%)	2 (5%)	2 (5%)

Sum of frequency and intensity scores: 0 or 1, negative (−); 2 or 3, moderately positive (+); 4 to 6, highly positive (++).
*Spearman correlation was used to analyze the correlation of clinicopathological variables and EET-related genes expression.

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