UTUC possesses both shared and tumor-specific molecular features with bladder UC. A, Venn diagram shows the comparison of deregulated genes in UTUC and bladder UC (BUC). The list of deregulated gene of UTUC is significantly overlapped with the deregulated genes in bladder UC, with 492 down-regulated and 564 up-regulated genes were shared. B, Unsupervised hierarchical clustering of 1140 genes deregulated in both UTUC and bladder UC. Both gene and sample clustering were done using average linkage and uncentered Pearson correlation metric by Cluster 3.0, and results were visualized by TreeView. Hierarchical trees of gene clustering are not shown. C, Unsupervised hierarchical clustering of 372 genes deregulated in UTUC, bladder UC as well as ccRCC. Analyses were done as described in B.