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Table 5 Frequency of EML4-ALK in Chinese NSCLC Patients (extracted from 6 published studies)

From: Non-small cell lung cancer with EML4-ALKtranslocation in Chinese male never-smokers is characterized with early-onset

Publication [ref] All Patients Never-smokers Smokers Female Male
Total EML4-ALK Total EML4-ALK Total EML4-ALK Total EML4-ALK Total EML4-ALK
  No. No. (%) No. No. (%) No. No. (%) No. No. (%) No. No. (%)
Rekova et al. 2007 [8] 103 3 (2.91%)         
Wong et al. 2009 [14] 266 13 (4.89%) 141 10 (7.09%) 125 3 (7.09%) 134 8 (5.97%) 132 5 (3.79%)
Zhang et al. 2010 [16] 103 12 (11.65%) 52 10 (19.23%) 51 2 (19.23%) 29 5 (17.24%) 74 7 (9.46%)
Shaozhang et al. 2012 [17] 102 8 (7.84%) 52 6 (11.54%) 50 2 (11.54%) 48 6 (12.50%) 54 2 (3.70%)
Li et al. 2013 [18] 208 7 (3.37%) 78 6 (7.69%) 130 1 (7.69%) 61 7 (11.48%) 147 0 (0.00%)
Sun et al. 2010 [28]    52 3 (5.77%)       
Sum 782 43 (5.5%) 375 35 (9.33%) 356 8 (2.25%) 272 26 (9.56%) 407 14 (3.44%)
  1. By Fisher’s exact test, the difference is significant between (i) never-smokers and smokers (p < 0.0001); (ii) Female and Male (p < 0.002).