Figure 5

Similar changes in protein expression pattern in plasma from patients and carriers (A) Principal Component Analysis using the 35 identified proteins with significant difference in expression between plasma samples from breast cancer patients, carrier and controls. The accession numbers of the identified proteins are indicated in the grey color, while Blue, cancer, Purple, carrier, and Orange, control. (B) Hierarchical Cluster Analysis using the expression profiles of the 35 identified proteins with significant difference between plasma samples from breast cancer patients, carrier and controls. (Blue, cancer, Purple, carrier, and Orange, control). (C) Histograms showing relative expression (quantitation), based on intensities, of10 out of the 35 differentially expressed proteins (The expression changes/ abundance ratio were calculated based on the averaged intensities of all identified peptides corresponding to an identification of a particular protein). (The proteins were identified by LC/MS/MS/Synapt G2 and the expression data was generated using Progenesis LC-MS/QI by Nonlinear Dynamics)”. The numbers on the x axis represent Normalized Averaged Intensities.