Platinum sensitivity and CD133 expression as risk and prognostic predictors of central nervous system metastases in patients with epithelial ovarian cancer

Table 3 Major clinical characteristics related to CNS metastases and its association with CD133 expression

Parameter	No. of patients (%)*						P value†	P value‡	P value§
	CD133-negative expression	CD133-positive expression			NA	Total
		Total	Single cell	Cluster
Age at the time of CNS metastasis(yrs)							0.228	0.342	1.000
<60	3 (27.3)	8 (72.7)	2 (18.2)	6 (54.5)	4	15
> = 60	0 (0)	8 (100.0)	2 (25.0)	6 (75.0)	6	14
KPS score							1.000	0.869	1.000
> = 80	1 (11.1)	8 (88.9)	2 (22.2)	6 (66.7)	5	14
<80	2 (20.0)	8 (80.0)	2 (20.0)	6 (60.0)	5	15
No. of metastases							0.546	0.149	0.118
Single	2 (25.0)	6 (75.0)	3 (37.5)	3 (37.5)	3	11
Multiple	1 (9.1)	10 (90.9)	1 (9.1)	9 (81.8)	7	18
Leptomeningeal dissemination							/	/	/
Yes	/	/	/	/	1	1
No	2	11	2	9	2	15
Unknown	1	5	2	3	7	13
Prior cancer relapse before the diagnosis of CNS metastasis							1.000	0.728	0.529
Yes	0 (0)	3 (100.0)	0 (0)	3 (100.0)	2	5
No	3 (18.8)	13 (81.3)	4 (25.0)	9 (56.3)	8	24
Presence of extracranial disease							1.000	1.000	1.000
Yes	1 (11.1)	8 (88.9)	2 (22.2)	6 (66.7)	4	13
No	2 (20.0)	8 (80.0)	2 (20.0)	6 (60.0)	6	16
CD133 expression in primary ovarian cancer							0.211	0.003	0.019
Negative	3	7	4	3	5	15
Positive	0	9	0	9	5	14
Treatment of CNS metastases							0.537^#	0.521^#	0.580^#
WBRT	/	/	/	/	7	7
Steroids	/	/	/	/	2	2
Neurosurgery	0 (0)	2 (100.0)	0 (0)	2 (100.0)	/	2
Neurosurgery + WBRT	1 (16.7)	5 (83.3)	1 (16.7)	4 (66.7)	/	6
Neurosurgery + WBRT + chemotherapy	0 (0)	4 (100.0)	1 (25.0)	3 (75.0)	/	4
Neurosurgery + SRS	1 (25.0)	3 (75.0)	1 (25.0)	2 (50.0)	/	4
Neurosurgery + SRS + chemotherapy	1 (33.3)	2 (66.7)	1 (33.3)	1 (33.3)	/	3
SRS + chemotherapy	/	/	/	/	1	1

Abbreviations: NA Not available, KPS Karnofsky performance status, WBRT Whole-brain radiation therapy, SRS Stereotactic radiosurgery.
*Percentage (%) represented the proportion of each group in 19 patients whose tumor tissues were available.
†P values were calculated by comparing CD133-negative vs. CD133-positive groups in 19 patients whose tumor tissues were available.
‡P values were calculated by comparing CD133-negative vs. CD133-positive single cell vs. CD133-positive cluster groups in 19 patients whose tumor tissues were available.
§P values were calculated by comparing CD133-positive single cell vs. CD133-positive cluster groups in 16 patients whose tumor tissues were stained CD133 positive.
^# P values were calculated by comparing neurosurgery + WBRT +/− chemotherapy vs. neurosurgery + SRS +/− chemotherapy groups.

ISSN: 1471-2407