Table 3 Univariate analysis for survival
| Â | 3Y-PFS, % (95% CI) | p | 3Y-OS % (95% CI) | p |
|---|---|---|---|---|
Gender | Â | 0.301 | Â | 0.571 |
  Male | 51 (37.7-64.3) | 70 (58.3-80.7) | ||
  Female | 80 (43.0-117.0) | 80 (44.9-115.1) | ||
Smoking | Â | 0.793 | Â | 0.642 |
  Never | 50 (28.2-71.4) | 73 (55.4-89.9) | ||
  Ex/current | 55 (39.7-71.3) | 69 (55.7-82.7) | ||
Alcohol | Â | 0.217 | Â | 0.338 |
  Never/social | 56 (42.0-70.6) | 72 (59.7-84.1) | ||
  Heavy | 45 (21.0-69.6) | 66 (44.1-88.4) | ||
Anatomic site | Â | 0.235 | Â | 0.563 |
  Tonsil | 59 (43.5-73.7) | 71 (57.7-84.4) | ||
  Others | 44 (21.6-65.8) | 69.2 (51.4-87.0) | ||
Clinical stage | Â | 0.952 | Â | 0.930 |
  III | 54 (39.4-68.8) | 72 (53.3-92.3) | ||
  IV | 53 (38.5-67.5) | 61 (42.7-78.7) | ||
T stage | Â | 0.005 | Â | 0.710 |
  T1-2 | 63 (47.7-79.1) | 77 (64.1-89.5) | ||
  T3-4 | 37 (17.6-56.8) | 61 (42.7-78.7) | ||
N stage | Â | 0.750 | Â | 0.805 |
  N0-1 | 54 (39.4-68.8) | 73 (53.3-93.3) | ||
  N2-3 | 51 (25.8-76.8) | 69 (56.3-81.7) | ||
PS (ECOG) | Â | 0.004 | Â | 0.003 |
  0 | 62 (44.3-80.0) |  | 85 (73.3-96.1) |  |
  1 | 26 (5.5-47.5) | 52 (34.4-69.6) | ||
Induction response | Â | 0.549 | Â | 0.002 |
  CR | 53 (29.2-75.8) | 94 (91.8-105.8) | ||
  Non-CR | 54 (39.2-69.0) | 61 (47.2-74.2) | ||
RT dose (cGy) | Â | 0.233 | Â | 0.006 |
  ≥6,500 | 57 (41.6-73.0) | 80 (67.5-92.5) | ||
  <6,500 | 46 (24.7-67.1) | 56 (38.4-73.6) | ||
RT type | Â | 0.132 | Â | 0.198 |
  3D-RT | 59 (42.5-67.8) | 74 (62.0-86.4) | ||
  IMRT | 73 (50.5-92.5) | 88.1 (78.1-98.1) | ||
Treatment duration | Â | 0.702 | Â | 0.258 |
  <4 months | 59 (36.3-81.0) | 75 (58.4-91.0) | ||
  ≥4 months | 53 (36.6-68.8) | 67 (53.3-81.5) | ||
HPV | Â | 0.078 | Â | 0.136 |
  Positive | 71 (52.0-90.8) | 81 (64.1-98.0) | ||
  Negative | 45 (29.0-60.4) | 66 (52.5-79.1) | ||
p16 | Â | 0.076 | Â | 0.014 |
  Positive | 61 (43.4-78.6) | 83 (70.4-95.4) | ||
  Negative | 46 (28.2-63.4) | 59 (42.6-75.2) | ||
p53 | Â | 0.655 | Â | 0.002 |
  Low | 43 (25.5-71.7) | 81 (69.8-92.2) | ||
  High | 49 (28.0-58.2) | 50 (30.1-70.5) | ||
ERCC1 | Â | 0.491 | Â | 0.355 |
  Low | 53 (31.2-74.4) | 64 (48.3-78.9) | ||
  High | 54 (26.8-82.0) | 70 (41.3-99.3) | ||
Class III beta tubulin | Â | 0.098 | Â | 0.012 |
  Low | 58 (43.1-72.5) | 77 (65.4-89.4) | ||
  High | 42 (18.4-66.2) | 54 (32.5-74.9) | ||
Bcl-2 | Â | 0.678 | Â | 0.217 |
  Low | 57 (40.6-72.8) | 64 (48.3-78.9) | ||
  High | 54 (26.8-82.0) | 70 (41.2-99.3) |