Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAs

BMC Cancer

Table 4 Differentially expressed miRNAs between malignant and non-malignant prostate tissues samples

miRNA	Median relative transcript levels (x10^-3)			Median fold expressions
	Tu	Tf	BPH	Tu vs Tf_[median]	Tu vs BPH_[median]
	(n = 50)	(n = 46)	(n = 30)
miR-101	1.52	2.91	2.01	−1.92**	−1.32
miR-138	0.19	1.08	1.06	−5.61**	−5.49**
miR-186	39.52	138.59	160.43	−3.51**	−4.06**
miR-224	1.19	4.12	3.22	−3.45**	−2.70**
miR-26a	179.04	380.81	310.84	−2.13**	−1.74**
miR-26b	51.77	69.98	60.60	−1.35 *	−1.17
miR-374a	17.63	39.65	33.84	−2.25**	−1.92**
miR-410	0.08	0.28	0.33	−3.64**	−4.29**
miR-660	13.46	22.50	22.63	−1.67**	−1.68**

Depicted are the median relative transcript levels of the evaluated miRNAs (normalized to RNU48) in Tu, matched Tf and BPH tissue samples as well as the median fold expressions of the Tu samples compared to the indicated control group. P values were calculated by the Mann–Whitney U test with a two-sided 95% confidence interval (*p < 0.05, **p < 0.01).

ISSN: 1471-2407