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Table 2 Meta-regression and subgroup analysis of the studies reporting the association between microRNA-21 and the overall survival of cancer patients

From: MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis

Stratified study

No. of studies

Pooled HR(95% CI)

Meta-regression

Heterogeneity

Fixed-Model

Random-Model

Tau2

Adj R2(%)

p-value

I2(%)

p-value

Year

   

0.246

3.79

0.350

  

  >2012

17

2.48(2.17,2.83)

2.46(2.02,2.99)

   

43.0

0.031

  ≤2012

14

1.53(1.29,1.81)

2.13(1.36,3.31)

   

83.3

0.001

CEA (cut-off value)

   

0.268

−4.75

0.848

  

  Mean & Median

25

2.06(1.84,2.30)

2.31(1.77,3.03)

   

80.4

0.001

  Others

6

2.11(1.53,2.92)

2.11(1.53,2.92)

   

0.0

0.822

Sample size

   

0.268

−4.48

0.216

  

  >100

15

1.85(1.53,2.22)

2.53(1.59,4.02)

   

82.1

0.001

  <=100

16

2.18(1.92,2.48)

2.12(1.67,2.69)

   

66.4

0.001

Race

   

0.260

−1.68

0.537

  

  Yellow

12

2.63(2.26,3.07)

2.67(2.07,3.42)

   

50.9

0.021

  White

18

1.63(1.41,1.88)

1.94(1.40,2.71)

   

78.7

0.001

Age

   

0.229

10.63

0.391

  

  <=60

12

2.42(2.08,2.82)

2.52(2.08,3.06)

   

32.2

0.088

  >60

19

1.80(1.56,2.07)

1.90(1.21,3.01)

   

87.9

0.001

TNM stage

   

0.263

−2.78

0.362

  

  I-IV

17

1.98(1.76,2.23)

2.16(1.16,2.92)

   

80.3

0.001

  Others

14

1.22(1.15,1.30)

1.86(1.53,2.26)

   

80.7

0.001

Cancer category

   

0.258

−0.55

0.421

  

  Digestive system

13

2.35(1.96,2.81)

2.43(1.95,3.03)

   

28.1

0.162

  Respiratory system

11

1.82(1.47,2.26)

2.08(1.40,3.08)

   

66.9

0.001

  Breast cancer

3

3.07(1.88,5.01)

4.08(1.23,13.48)

   

81.4

0.005

  Others systems

4

1.89(1.60,2.25)

1.68(0.76,3.73)

   

95.0

0.001

Detect Method

   

0.270

−5.34

0.686

  

  qPCR

29

2.27(1.81,2.86)

2.07(1.86,2.29)

   

76.0

0.001

  others

2

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Overall

31

2.07(1.86,2.29)

2.27(1.81, 2.86)

   

76.0

0.001

  1. Abbreviations: CI confidence interval, HR hazard ratio.