From: MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis
Stratified study | No. of studies | Pooled HR(95% CI) | Meta-regression | Heterogeneity | ||||
---|---|---|---|---|---|---|---|---|
Fixed-Model | Random-Model | Tau2 | Adj R2(%) | p-value | I2(%) | p-value | ||
Year | Â | Â | Â | 0.246 | 3.79 | 0.350 | Â | Â |
  >2012 | 17 | 2.48(2.17,2.83) | 2.46(2.02,2.99) |  |  |  | 43.0 | 0.031 |
  ≤2012 | 14 | 1.53(1.29,1.81) | 2.13(1.36,3.31) |  |  |  | 83.3 | 0.001 |
CEA (cut-off value) |  |  |  | 0.268 | −4.75 | 0.848 |  |  |
  Mean & Median | 25 | 2.06(1.84,2.30) | 2.31(1.77,3.03) |  |  |  | 80.4 | 0.001 |
  Others | 6 | 2.11(1.53,2.92) | 2.11(1.53,2.92) |  |  |  | 0.0 | 0.822 |
Sample size |  |  |  | 0.268 | −4.48 | 0.216 |  |  |
  >100 | 15 | 1.85(1.53,2.22) | 2.53(1.59,4.02) |  |  |  | 82.1 | 0.001 |
  <=100 | 16 | 2.18(1.92,2.48) | 2.12(1.67,2.69) |  |  |  | 66.4 | 0.001 |
Race |  |  |  | 0.260 | −1.68 | 0.537 |  |  |
  Yellow | 12 | 2.63(2.26,3.07) | 2.67(2.07,3.42) |  |  |  | 50.9 | 0.021 |
  White | 18 | 1.63(1.41,1.88) | 1.94(1.40,2.71) |  |  |  | 78.7 | 0.001 |
Age | Â | Â | Â | 0.229 | 10.63 | 0.391 | Â | Â |
  <=60 | 12 | 2.42(2.08,2.82) | 2.52(2.08,3.06) |  |  |  | 32.2 | 0.088 |
  >60 | 19 | 1.80(1.56,2.07) | 1.90(1.21,3.01) |  |  |  | 87.9 | 0.001 |
TNM stage |  |  |  | 0.263 | −2.78 | 0.362 |  |  |
  I-IV | 17 | 1.98(1.76,2.23) | 2.16(1.16,2.92) |  |  |  | 80.3 | 0.001 |
  Others | 14 | 1.22(1.15,1.30) | 1.86(1.53,2.26) |  |  |  | 80.7 | 0.001 |
Cancer category |  |  |  | 0.258 | −0.55 | 0.421 |  |  |
  Digestive system | 13 | 2.35(1.96,2.81) | 2.43(1.95,3.03) |  |  |  | 28.1 | 0.162 |
  Respiratory system | 11 | 1.82(1.47,2.26) | 2.08(1.40,3.08) |  |  |  | 66.9 | 0.001 |
  Breast cancer | 3 | 3.07(1.88,5.01) | 4.08(1.23,13.48) |  |  |  | 81.4 | 0.005 |
  Others systems | 4 | 1.89(1.60,2.25) | 1.68(0.76,3.73) |  |  |  | 95.0 | 0.001 |
Detect Method |  |  |  | 0.270 | −5.34 | 0.686 |  |  |
  qPCR | 29 | 2.27(1.81,2.86) | 2.07(1.86,2.29) |  |  |  | 76.0 | 0.001 |
  others | 2 | ------ | ------ | ------ | ------ | ------ |  |  |
Overall | 31 | 2.07(1.86,2.29) | 2.27(1.81, 2.86) | Â | Â | Â | 76.0 | 0.001 |