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Table 2 Associations between number of AR CAG repeats and ESR2 CA repeats and overall as well as disease-specific survival

From: Repeat polymorphisms in ESR2 and ARand colorectal cancer risk and prognosis: results from a German population-based case-control study

 

Overall

Women

Men

pheterogeneityc

Genotype

OS HR (95%CI)b

DSS HR (95%CI)b

OS HR (95% CI)b

DSS HR (95%CI)b

OS HR (95%CI)b

DSS HR (95% CI)b

OS

DSS

AR CAG( n)

        

<20 average repeats

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

  

≥20 to <22 average repeats

1.09 (0.78 - 1.53)

1.14 (0.77 - 1.69)

0.90 (0.50 - 1.62)

1.21 (0.59 - 2.47)

1.28 (0.84 - 1.97)

1.20 (0.73 - 2.00)

  

≥22 to <23.5 average repeats

1.11 (0.76 - 1.61)

1.26 (0.82 - 1.95)

0.90 (0.49 - 1.64)

1.17 (0.56 - 2.46)

1.12 (0.67 - 1.88)

1.34 (0.74 - 2.42)

  

≥23.5 average repeats

1.03 (0.72 - 1.46)

1.04 (0.69 - 1.58)

0.75 (0.41 - 1.37)

0.93 (0.44 - 1.96)

1.22 (0.78 - 1.91)

1.24 (0.72 - 2.12)

0.83c

0.99c

average repeatsa

1.00 (0.96 - 1.05)

1.01 (0.95 - 1.06)

0.96 (0.88 - 1.04)

0.98 (0.89 - 1.08)

1.02 (0.96 - 1.07)

1.03 (0.96 - 1.10)

0.45d

0.93d

 

p trend =0.97

p trend =0.84

p trend =0.31

p trend =0.67

p trend =0.56

p trend =0.46

  

<22/<22 repeats

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

  

<22/≥22 repeats

0.95 (0.70 - 1.28)

0.95 (0.66 - 1.36)

0.96 (0.62 - 1.49)

0.97 (0.59 - 1.60)

(no heterozygous)

(no heterozygous)

  

≥22/≥22 repeats

1.03 (0.80 - 1.33)

1.12 (0.84 - 1.51)

0.94 (0.58 - 1.53)

1.09 (0.63 - 1.89)

1.01 (0.74 - 1.37)

1.14 (0.78 - 1.65)

0.91d

0.60d

 

p trend =0.80

p trend =0.45

p trend =0.82

p trend =0.73

p trend =0.95

p trend =0.50

  

ESR2 CA( n)

        

<22 average repeats

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

  

≥22 to <23.5average repeats

0.82 (0.59 - 1.15)

0.92 (0.61 - 1.39)

0.66 (0.38 - 1.15)

0.79 (0.42 - 1.47)

0.76 (0.51 - 1.14)

1.11 (0.63 - 1.97)

  

≥23.5 to <24 average repeats

0.93 (0.64 - 1.35)

1.12 (0.73 - 1.73)

1.15 (0.67 - 1.98)

1.16 (0.61 - 2.20)

0.91 (0.54 - 1.53)

1.30 (0.69 - 2.44)

  

≥24 average repeats

0.76 (0.56 - 1.02)

0.91 (0.64 - 1.29)

0.73 (0.47 - 1.15)

0.80 (0.50 - 1.38)

0.83 (0.50 - 1.38)

1.00 (0.60 - 1.65)

0.56c

0.96c

average repeatsa

0.95 (0.89 - 1.02)

0.99 (0.91 - 1.07)

0.95 (0.86 - 1.06)

0.96 (0.86 - 1.08)

0.95 (0.86 - 1.03)

1.00 (0.89 - 1.12)

0.85d

0.81d

 

p trend =0.14

p trend =0.72

p trend =0.35

p trend =0.54

p trend =0.22

p trend =0.99

  

<24/<24 repeats

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

  

<24/≥24 repeats

0.79 (0.59 - 1.07)

0.88 (0.62 - 1.26)

0.74 (0.46 - 1.20)

0.89 (0.51 - 1.55)

0.88 (0.60 - 1.29)

0.99 (0.62- 1.58)

  

≥24/≥24 repeats

0.73 (0.53 - 1.00)

0.82 (0.57 - 1.19)

0.67 (0.40 - 1.12)

0.78 (0.43 - 1.40)

0.76 (0.51 - 1.15)

0.89 (0.54 - 1.46)

0.81d

0.84d

 

p trend =0.06

p trend =0.31

p trend =0.15

p trend =0.39

p trend =0.19

p trend =0.62

  
  1. aAs continuous variable, bStratified for grade of differentiation (well/moderate, poor/undifferentiated) and adjusted for diagnosis of other cancer after colorectal cancer diagnosis (yes/no), colorectal cancer detected by screening (yes/no), treatment with adjuvant chemotherapy (yes/no), tumour extent (T1, T2, T3, T4), nodal status (N0, N1, N2), distant metastasis (M0, M1), BMI (kg/m2, continuous), age at diagnosis and year of diagnosis, cP-value for heterogeneity by gender with genotype in categories (3df), dP-value for heterogeneity by gender with genotype as continuous variable (1df), OS: overall survival, DSS: disease-specific survival, HR: hazard ratio, CI: confidence interval.
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BMC Cancer

ISSN: 1471-2407

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