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Table 1 Number of AR CAG repeats and ESR2 CA repeats and associated colorectal cancer risk in the female and male study population

From: Repeat polymorphisms in ESR2 and ARand colorectal cancer risk and prognosis: results from a German population-based case-control study

  Overall Women Men  
Genotype Cases N Controls N OR (95% CI)b Cases N Controls N OR (95% CI)c Cases N Controls N OR (95%CI)c pheterogeneity
AR CAG( n)     
<20 average repeats 263 254 1.00 (Ref.) 88 94 1.00 (Ref.) 175 160 1.00 (Ref.)  
≥20 to <22 average repeats 531 506 1.01 (0.82 - 1.25) 229 228 1.06 (0.75 - 1.51) 302 278 1.00 (0.76 - 1.31)  
≥22 to <23.5 average repeats 370 400 0.89 (0.71 - 1.11) 182 189 1.03 (0.72 - 1.48) 188 211 0.82 (0.61 - 1.10)  
≥23.5 average repeats 424 412 0.99 (0.79 - 1.23) 169 140 1.24 (0.85 - 1.80) 255 272 0.86 (0.65 - 1.13) 0.19d
average repeatsa 1588 1572 0.99 (0.96 - 1.01) 668 651 1.01 (0.96 - 1.06) 920 921 0.98 (0.95 - 1.01) 0.23e
    p trend =0.34    p trend =0.68    p trend =0.15  
<22/<22 repeats 645 610 1.00 (Ref.) 168 172 1.00 (Ref.) 477 438 1.00 (Ref.)  
<22/≥22 repeats 324 324 0.91 (0.72 - 1.15) 324 324 1.03 (0.79 - 1.35) n/a n/a (no heterozygous)  
≥22/≥22 repeats 619 638 0.91 (0.78 - 1.07) 176 155 1.14 (0.84 - 1.55) 443 483 0.84 (0.70 - 1.01) 0.09e
    p trend =0.24    p trend =0.40    p trend =0.07  
ESR2 CA( n)           
<22 average repeats 348 409 1.00 (Ref.) 149 153 1.00 (Ref.) 199 256 1.00 (Ref.)  
≥22 to <23.5average repeats 389 381 1.20 (0.98 - 1.47) 154 154 1.07 (0.77 - 1.49) 235 227 1.25 (0.96 - 1.64)  
≥23.5 to <24 average repeats 226 227 1.17 (0.93 - 1.48) 98 90 1.14 (0.77 - 1.68) 128 137 1.20 (0.87 - 1.65)  
≥24 average repeats 618 602 1.20 (1.00 - 1.45) 261 255 1.06 (0.78 - 1.46) 357 347 1.31 (1.02 - 1.70) 0.51d
average repeatsa 1581 1619 1.05 (1.01 - 1.10) 662 652 1.01 (0.95 - 1.08) 919 967 1.07 (1.02 - 1.13) 0.24e
    p trend =0.02    p trend =0.69    p trend =0.01  
<24/<24 repeats 323 347 1.00 (Ref.) 119 125 1.00 (Ref.) 204 222 1.00 (Ref.)  
<24/≥24 repeats 755 814 0.99 (0.83 - 1.19) 335 334 1.03 (0.77 - 1.39) 420 480 0.95 (0.75 - 1.20)  
≥24/≥24 repeats 503 458 1.17 (0.96 - 1.43) 208 193 1.10 (0.80 - 1.52) 295 265 1.21 (0.94 - 1.55) 0.71e
    p trend =0.08    p trend =0.54    p trend =0.11  
  1. aAs continuous variable, bModels adjusted for sex, county of residence and age, cModels adjusted for county of residence and age, d P value for heterogeneity by gender with genotype in categories (3 df), e P value for heterogeneity by gender with genotype as continuous variable (1 df), OR: odds ratio, CI: confidence interval.