Multimodal therapy in treatment of rectal cancer is associated with improved survival and reduced local recurrence - a retrospective analysis over two decades

Table 3 Percentage of neoadjuvant and adjuvant therapy performed in each time period over all patients

Therapy all patients	1993-2001 (n=301)		2002. 2010 (n=357)		p-value
Therapy all patients	No.	%	No.	%	p-value
Neoadjuvant
No	248	82.4	143	40	<0.001
Chemo	1	0.3	3	0.8	n.s.
Radio	36	12	83	23.3	0.011
Radiochemo	16	5.3	126	35.3	<0.001
Unknown	0	0	2	0.6	n.s.
Adjuvant
No	187	62.1	149	41.6	<0.001
Chemo	48	16	162	45.3	<0.001
Radio	19	6.3	8	2.2	0.009
Radiochemo	33	11	20	5.9	0.02
Unknown	14	4.7	18	5.0	n.s.

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