Multimodal therapy in treatment of rectal cancer is associated with improved survival and reduced local recurrence - a retrospective analysis over two decades

Table 1 Characteristics of 658 patients treated between 1993–2010 for rectal cancer at the University hospital of Wuerzburg

Characteristic	1993-2001 (n=301)		2002..2010 (n=357)		p-value
Characteristic	No.	%	No.	%	p-value
Sex					0.035
Male	182		244
Female	119		113
Age, years					n.s.
Median	66.16 (+/−11.88)		66.83 (+/−11.5)
Range	22.06-93.6		27.7-93.6
pUICC
0	0	0	15	4.2	<0.0001
I	95	28.6	127	35.6	n.s.
II	58	19.3	67	18.8	n.s.
III	62	20.6	79	22.1	n.s.
IV	67	22.3	64	17.9	n.s.
X	19	6.3	5	1.4	<0.001
cUICC
I	81	26.9	79	22.1	n.s.
II	75	24.9	69	19.3	n.s.
III	67	22.3	135	37.8	<0.001
IV	66	21.9	69	19.3	n.s.
X	12	4	5	1.4	0.037
Patho. T-stage
pT0	0	0	18	5	<0.001
pT 1,2	118	39.2	163	45.7	n.s.
pT3	124	41.2	129	36.1	n.s.
pT4	29	9.6	13	3.6	0.002
pTx	30	10	30	8.4	n.s.
pTis	0	0	3	0.8	n.s.
Patho. N-stage
pN0	149	49.5	216	60.5	0.005
pN1	52	17.3	65	18.2	n.s.
pN2	61	20.2	38	10.6	<0.001
pNx	39	13	37	10.4	n.s.
Distance to anal verge
<4cm	59	19.6	121	33.9	<0.001
4-8cm	96	31.9	129	36.1	n.s.
8-12cm	104	34.6	81	22.7	<0.001
>12cm	36	12	24	6.7	0.02
x	6	2	1	0.5	0.033
Clinical T-stage
cT1,2	95	31.6	81	22.7	0.01
cT3,4	179	59.5	248	69.5	0.007
cTx	27	9	28	7.8	n.s.
Clinical N-stage
N0	140	46.5	128	35.9	0.006
cN+	91	30.3	182	51	<0.001
cNx	70	23.2	47	13.2	<0.001

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