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Table 3 Multivariate analysis of factors influencing overall survival

From: Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma

Multivariate cox regression

p

HR

CI

(Overall survival)

Resection (yes vs no) - unadjusted

< 0.001

0.306

0.266 - 0.351

Resection (yes vs no) - adjusted

< 0.001

0.355

0.305 - 0.414

Age

< 0.001

1.017

1.012 - 1.023

Sex (female vs male)

0.298

1.062

0.948 - 1.189

Year of metastasis

0.879

1.003

0.970

Synchronous vs Metachronous

0.799

0.983

1.036

Number of CLM 1

 

1.000

 

Number of CLM 2-3

< 0.001

1.067

0.864 - 1.119

Number of CLM >3

0.576

1.659

0.850 - 1.340

Number unknown

< 0.001

1.430

1.387 - 1.985

Chemotherapy (yes vs no)

< 0.001

0.606

0.540 - 0.681

  1. Univariate and multivariate analysis, adjusted for age, sex, year of resection, time after primary tumour and number of metastasis, revealed significant OS benefit for CLM resection (HR =0.355).
  2. In multivariate analysis, significant impact on OS was seen for age at diagnosis, number of CLM, and chemotherapeutic treatment. No significant influence on OS was seen for the parameters sex, year of resection, time of CLM diagnosis after primary tumour (metachronousvs synchronous). p = Level of significance, HR = Hazard ratio, CI =95% confidence interval.