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Table 2 List of genes involved in the gene networks that are differentially regulated between mammary epithelial cells in the ( C vs H and C’ vs H’ ) comparison

From: A genomics approach to identify susceptibilities of breast cancer cells to “fever-range” hyperthermia

Gene symbol Gene name Accession number MCF-10A MCF-7 MDA-231 MDA-468
DNA Damage       
USP1 Ubiquitin specific peptidase 1, TV3 NM_001017416.1 4.8 -1.8 -2.2 -5.3
CDC25A Cell division cycle 25A, TV1 NM_001789.2 4.6 -1.3 1.2 2.0
BARD1 BRCA1 associated RING domain 1 NM_000465.1 3.5 -1.7 -2.8 -1.7
MDC1 Mediator of DNA-damage checkpoint 1 NM_014641.1 3.0 -1.4 1.1 -1.2
NBN Nibrin NM_002485.4 2.5 -2.4 -2.2 -1.1
SLC35B2 Solute carrier family 35, member B2 NM_178148.1 2.3 -1.0 1.8 1.8
CHEK1 Checkpoint kinase 1, TV3 NM_001274.3 2.3 -1.1 -1.4 -2.6
CCNE1 Cyclin E1, TV2 NM_057182.1 2.1 -1.2 -1.1 -1.0
CCNA1 Cyclin A1, TV1 NM_003914.2 -2.2 1.2 1.0 -1.3
GADD45B Growth arrest and DNA-damage-inducible, beta NM_015675.2 -3.8 1.1 1.8 -1.1
CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1), TV1 NM_000389.2 -4.7 1.1 2.5 1.1
Cell Cycle       
AURKA Aurora kinase A, TV5 NM_198436.1 22.0 -1.3 -2.1 1.2
CDC20 Cell division cycle 20 NM_001255.2 18.0 1.1 -1.1 -1.2
CCNB2 Cyclin B2 NM_004701.2 17.5 -1.3 -2.3 -1.1
NCAPG Non-SMC condensin I complex, subunit G, TV1 NM_022346.3 14.9 -1.4 -2.6 -1.1
BUB1 Budding uninhibited by benzimidazoles 1 homolog (yeast) NM_004336.2 10.8 -1.5 -2.3 1.2
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) NM_002358.2 9.8 -1.5 -1.6 2.1
CDC45L Cell division cycle 45, TV2 NM_003504.3 8.0 1.1 1.4 1.1
CENPF Centromere protein F, 350/400 kDa NM_016343.3 7.8 -1.3 -3.0 1.1
PTTG1 Pituitary tumor-transforming 1 NM_004219.2 7.2 1.0 -1.0 1.4
MCM3 Minichromosome maintenance complex component 3, TV1 NM_002388.3 7.2 -1.5 -1.1 -1.4
CCNB1 Cyclin B1 NM_031966.2 6.9 -1.2 -2.5 1.1
CENPE Centromere protein E, 312 kDa NM_001813.2 6.6 -1.4 -2.5 -1.5
KIF11 Kinesin family member 11 NM_004523.2 6.5 -1.4 -2.7 -1.0
NDC80 NDC80 kinetochore complex component NM_006101.1 6.5 -1.1 -1.8 1.4
XPO1 Exportin 1 (CRM1 homolog, yeast) NM_003400.3 6.1 -2.7 -2.4 -3.0
RFC5 Replication factor C (activator 1) 5, 36.5 kDa, TV1 NM_007370.3 5.8 -1.2 -1.1 1.7
POLA1 Polymerase (DNA directed), alpha 1, catalytic subunit NM_016937.2 5.7 -1.5 -1.8 -1.2
RFC4 Replication factor C (activator 1) 4, 37 kDa, TV2 NM_181573.1 5.6 -1.2 -1.4 -1.4
CDC2 Cyclin-dependent kinase 1, TV1 NM_001786.2 5.2 -1.2 -2.3 1.7
CENPA Centromere protein A, TV2 NM_001042426.1 4.9 -1.3 -1.7 1.3
CKS1B CDC28 protein kinase regulatory subunit 1B, TV1 NM_001826.1 4.8 -1.2 -1.3 1.6
DSN1 MIND kinetochore complex component, TV3 NM_024918.2 4.7 -1.3 -1.8 -1.1
CDC25A Cell division cycle 25A, TV1 NM_001789.2 4.6 -1.3 1.2 2.0
NUF2 NDC80 kinetochore complex component, TV2 NM_031423.3 4.3 1.0 -2.0 1.7
PPP2CA Protein phosphatase 2, catalytic subunit, alpha isozyme NM_002715.2 4.3 -1.8 -2.0 -2.6
PRIM1 Primase, DNA, polypeptide 1 (49 kDa) NM_000946.2 4.2 1.0 -1.0 1.8
YWHAH Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide NM_003405.3 4.0 -1.9 -1.6 -3.9
TUBB Tubulin, beta class I NM_178014.2 3.9 -1.1 1.3 1.9
STAG2 Stromal antigen 2, TV2 NM_001042750.1 3.9 -2.8 -2.4 -3.4
CSE1L CSE1 chromosome segregation 1-like (yeast), TV2 NM_177436.1 3.8 -1.4 -1.6 1.3
MCM6 Minichromosome maintenance complex component 6 NM_005915.4 3.8 -1.3 -1.4 -3.4
RPA1 Replication protein A1, 70 kDa NM_002945.2 3.7 -1.3 -1.2 1.1
TOP2B Topoisomerase (DNA) II beta 180 kDa NM_001068.2 3.7 -2.5 -2.6 -2.0
RALA V-ral simian leukemia viral oncogene homolog A (ras related) NM_005402.2 3.6 -1.7 -1.6 -2.3
SPC25 SPC25, NDC80 kinetochore complex component NM_020675.3 3.6 -1.1 -1.4 1.4
MAPK13 Mitogen-activated protein kinase 13, TV1 NM_002754.3 3.6 1.1 1.3 -1.2
RPA3 Replication protein A3, 14 kDa NM_002947.3 3.5 -1.2 -1.1 -1.3
E2F3 E2F transcription factor 3, TV1 NM_001949.2 3.5 -2.0 -2.2 -4.5
MCM10 Minichromosome maintenance complex component 10, TV2 NM_018518.3 3.4 -1.2 -1.2 2.3
NEK2 NIMA-related kinase 2, TV1 NM_002497.2 3.4 -1.1 -2.1 1.1
MAP2K4 Mitogen-activated protein kinase kinase 4 NM_003010.2 3.3 -2.3 -2.5 -3.1
DYNC1H1 Dynein, cytoplasmic 1, heavy chain 1 NM_001376.2 3.3 -2.1 -1.1 1.2
KIF22 Kinesin family member 22, TV1 NM_007317.1 3.2 -1.1 -1.1 1.1
RPA2 Replication protein A2, 32 kDa NM_002946.3 3.2 -1.0 1.0 1.4
CDC7 Cell division cycle 7, TV1 NM_003503.2 3.2 -1.3 -1.8 -3.1
RBL1 Retinoblastoma-like 1 (p107), TV1 NM_002895.2 3.2 -1.1 -2.0 1.4
MCM5 Minichromosome maintenance complex component 5 NM_006739.3 3.1 1.1 1.8 1.8
TGFB2 Transforming growth factor, beta 2 NM_003238.1 3.0 1.2 -1.4 1.7
E2F2 E2F transcription factor 2 NM_004091.2 3.0 -1.7 1.2 -3.7
CDCA1 Cell division cycle associated 1, TV1 NM_145697.1 3.0 1.1 -2.3 1.9
ITGB1 Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), TV1 NM_002211.2 3.0 -1.7 -1.2 1.4
MCM2 Minichromosome maintenance complex component 2, TV1 NM_004526.2 3.0 1.0 1.7 1.8
RFC3 Replication factor C (activator 1) 3, 38 kDa, TV1 NM_002915.3 2.9 -1.7 -1.8 -2.2
NEDD8 Neural precursor cell expressed, developmentally down-regulated 8 NM_006156.2 2.9 -1.1 -1.0 1.4
BIRC5 Baculoviral IAP repeat containing 5, TV3 NM_001012271.1 2.9 -1.1 -1.4 1.2
RPS6KB1 Ribosomal protein S6 kinase, 70 kDa, polypeptide 1, TV1 NM_003161.2 2.9 -3.4 -1.8 -1.2
KPNA4 Karyopherin alpha 4 (importin alpha 3) NM_002268.3 2.8 -1.3 -2.1 -1.1
PPP1CB Protein phosphatase 1, catalytic subunit, beta isozyme, TV3 NM_206876.1 2.7 -2.6 -2.9 -1.1
PLK1 Polo-like kinase 1 NM_005030.3 2.7 1.1 -1.1 1.2
CDK6 Cyclin-dependent kinase 6, TV1 NM_001259.5 2.7 -1.5 -2.9 2.1
NEK6 NIMA-related kinase 6, TV2 NM_014397.3 2.7 1.1 -1.2 1.1
KPNB1 Karyopherin (importin) beta 1, TV1 NM_002265.4 2.7 -1.2 -1.2 1.1
RAD21 RAD21 homolog (S. pombe) NM_006265.1 2.7 -1.7 -1.7 1.4
DSCC1 Defective in sister chromatid cohesion 1 NM_024094.1 2.7 -1.6 -1.6 -1.4
TNPO1 Transportin 1, TV2 NM_153188.2 2.7 -1.6 -2.4 1.1
YWHAB Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, TV1 NM_003404.3 2.6 1.1 -1.1 -1.5
TUBG1 Tubulin, gamma 1 NM_001070.3 2.6 1.0 -1.0 -1.0
FBXW11 F-box and WD repeat domain containing 11, TV1 NM_033645.2 2.6 -2.3 -2.3 1.4
BUB3 Budding uninhibited by benzimidazoles 3 homolog (yeast), TV2 NM_001007793.1 2.6 1.1 -1.1 -3.0
TUBA1B Tubulin, alpha 1b NM_006082.2 2.6 1.1 1.2 1.7
DYNC1LI2 Dynein, cytoplasmic 1, light intermediate chain 2 NM_006141.2 2.6 -2.5 -1.5 -1.2
TUBB2A Tubulin, beta 2A class IIa NM_001069.2 2.5 1.3 1.5 -1.4
CHUK Conserved helix-loop-helix ubiquitous kinase NM_001278.3 2.5 -1.9 -2.1 1.7
IPO5 Importin 5 NM_002271.4 2.5 -1.2 -2.0 1.3
RAN RAN, member RAS oncogene family NM_006325.2 2.5 -1.4 -1.5 1.6
RASSF1 Ras association (RalGDS/AF-6) domain family member 1, TVA NM_007182.4 2.5 1.2 1.4 -1.1
INCENP Inner centromere protein antigens 135/155 kDa, TV1 NM_001040694.1 2.5 -1.2 -1.2 2.0
DYNLT3 Dynein, light chain, Tctex-type 3 NM_006520.1 2.5 -1.3 -1.8 1.7
NCAPD3 Non-SMC condensin II complex, subunit D3 NM_015261.2 2.5 -1.1 1.2 -2.6
YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide NM_006826.2 2.5 -1.2 -1.4 1.8
TFDP1 Transcription factor Dp-1, TV1 NM_007111.3 2.4 -1.4 -1.5 -3.9
PDS5A PDS5, regulator of cohesion maintenance, TV2 NM_015200.1 2.4 -2.4 -2.1 1.9
MIS12 MIS12, MIND kinetochore complex component, TV2 NM_024039.1 2.4 -1.5 -1.5 -3.4
CDC23 Cell division cycle 23 NM_004661.3 2.4 -1.3 -1.2 1.3
POLS PAP associated domain containing 7, TV1 NM_006999.3 2.4 -1.8 -1.5 -3.4
CDC25C Cell division cycle 25C, TV1 NM_001790.3 2.3 1.1 1.1 1.1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B NM_001211.4 2.3 -1.1 -1.4 -2.0
ANAPC11 Anaphase promoting complex subunit 11, TV4 NM_001002246.1 2.3 1.1 1.1 -2.3
CHEK1 Checkpoint kinase 1, TV3 NM_001274.3 2.3 -1.1 -1.4 1.4
ZW10 Zw10 kinetochore protein NM_004724.2 2.3 -1.4 -1.9 -1.2
SMC2 Structural maintenance of chromosomes 2, TV1 NM_001042550.1 2.3 -1.6 -1.8 -1.3
CUL1 Cullin 1 NM_003592.2 2.3 -1.6 -1.8 -4.5
TUBA1C Tubulin, alpha 1c NM_032704.3 2.2 1.0 1.0 2.3
SMC4 Structural maintenance of chromosomes 4, TV2 NM_001002800.1 2.2 1.4 -2.0 1.1
CAPZA2 Capping protein (actin filament) muscle Z-line, alpha 2 NM_006136.2 2.2 -2.0 -1.3 -3.1
PCNA Proliferating cell nuclear antigen NM_182649.1 2.1 -1.1 -1.4 1.2
PPP2R5C Protein phosphatase 2, regulatory subunit B', gamma isoform , TV4 NM_178588.1 2.1 -1.0 -1.2 1.1
SKP1A S-phase kinase-associated protein 1, TV1 NM_006930.2 2.1 -1.4 -1.8 1.4
TGFBR2 Transforming growth factor, beta receptor II (70/80 kDa), TV1 NM_001024847.1 2.1 -1.5 -1.8 -3.1
CHTF18 CTF18, chromosome transmission fidelity factor 18 NM_022092.1 2.1 -1.1 1.3 1.4
CCNE1 Cyclin E1, TV2 NM_057182.1 2.1 -1.2 -1.1 1.8
YWHAZ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide NM_003406.2 2.1 -1.6 -1.6 1.7
CCT8 Chaperonin containing TCP1, subunit 8 (theta) NM_006585.2 2.1 -1.3 -1.8 -3.7
TUBB4Q Tubulin, beta polypeptide 4, member Q, pseudogene NM_020040.3 2.1 -1.0 1.2 1.9
WEE1 WEE1 homolog (S. pombe), TV1 NM_003390.2 2.1 -1.7 -2.2 1.4
RB1 Retinoblastoma 1 NM_000321.2 2.0 -1.4 -1.7 1.8
PPP2R5B Protein phosphatase 2, regulatory subunit B', beta NM_006244.2 -2.0 -1.0 1.2 -2.2
CCNA1 Cyclin A1, TV1 NM_003914.2 -2.2 1.2 1.0 1.4
TOB1 Transducer of ERBB2, 1, TV1 NM_005749.2 -2.3 -1.3 -1.4 1.2
LIMK2 LIM domain kinase 2, TV1 NM_001031801.1 -2.3 1.2 1.5 -1.2
MYL5 Myosin, light chain 5, regulatory NM_002477.1 -2.5 1.3 1.5 -1.1
TP63 Tumor protein p63, TV5 NM_001114981.1 -3.8 -1.1 3.7 -1.1
JUNB Jun B proto-oncogene NM_002229.2 -4.3 -1.2 1.6 1.2
PIK3R1 Phosphoinositide-3-kinase, regulatory subunit 1 (alpha), TV1 NM_181523.1 -4.7 -2.1 1.7 2.1
CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1) NM_000389.2 -4.7 1.1 2.5 1.1
RAC1 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Rac1b NM_018890.2 -7.6 -1.0 1.6 1.1
FOS FBJ murine osteosarcoma viral oncogene homolog NM_005252.2 -14.9 1.0 2.4 1.4
Apoptosis       
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 NM_002577.3 6.0 -2.9 -3.1 -1.3
CDC2 Cyclin-dependent kinase 1, TV1 NM_001786.2 5.2 -1.2 -2.3 1.7
BARD1 BRCA1 associated RING domain 1 NM_000465.1 3.5 -1.7 -2.8 -1.7
MAP2K4 Mitogen-activated protein kinase kinase 4 NM_003010.2 3.3 -2.3 -2.5 -3.1
MAP3K4 Mitogen-activated protein kinase kinase kinase 4, TV1 NM_005922.2 2.6 -1.6 -2.2 -2.5
MAP3K1 Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase NM_005921.1 2.6 -2.4 -1.6 -3.8
BIRC2 Baculoviral IAP repeat containing 2, TV1 NM_001166.3 2.6 -1.4 -2.1 1.5
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 NM_021627.2 2.5 -1.7 -1.8 -1.6
RIPK1 Receptor (TNFRSF)-interacting serine-threonine kinase 1 NM_003804.3 2.5 -1.7 -2.1 -4.5
YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide NM_006826.2 2.5 -1.2 -1.4 -2.1
MAPK9 Mitogen-activated protein kinase 9, TV JNK2-a2 NM_002752.3 2.4 -1.3 -1.5 -2.5
CASP3 Caspase 3, apoptosis-related cysteine peptidase, TV beta NM_032991.2 2.2 -1.3 -1.7 -4.0
APAF1 Apoptotic peptidase activating factor 1, TV1 NM_013229.2 2.2 -1.5 -1.4 -2.0
BMF Bcl2 modifying factor, TV2 NM_033503.3 -2.0 1.0 1.1 -1.2
CFLAR CASP8 and FADD-like apoptosis regulator NM_003879.3 -2.3 1.2 1.1 -1.9
HSPB1 Heat shock 27 kDa protein 1 NM_001540.2 -2.7 1.2 1.5 -1.1
GADD45B Growth arrest and DNA-damage-inducible, beta NM_015675.2 -3.8 1.1 1.8 -1.1
TNFRSF6B Tumor necrosis factor receptor superfamily, member 6b, decoy, transcript variant M68C NM_032945.2 -4.3 -1.0 1.2 1.8
Heat Shock       
HSP90AA1 Heat shock protein 90 kDa, class A member 1 NM_001017963.2 4.0 -1.4 -1.7 1.1
CARHSP1 Calcium regulated heat stable protein 1, 24 kDa NM_001042476.1 3.2 1.0 1.1 -1.1
HSPA12A Heat shock protein 70 kDa 12A NM_025015.2 2.3 -1.2 -1.7 1.4
HSPB1 Heat shock protein 27 kDa protein 1 NM_001540.2 -2.7 1.2 1.5 -1.1
HSPBL2 Heat shock 27 kDa protein 1 pseudogene 1 NR_024392.1 -3.2 1.2 1.6 -1.0
HSPA6 Heat shock 70 kDa protein 6 NM_002155.3 -5.3 1.2 1.1 1.3
HSPA7 Heat shock 70 kDa protein 7 NR_024151.1 -4.0 1.2 1.4 1.2