Table 3 Definition of risk and required surveillance in survivors at HIGH risk of a late effect

Definition of high risk group

Female, ≥20 Gy radiation therapy to the chest

≥30 Gy radiation therapy to the abdomen, pelvis or spine

Anthracycline +/− chest radiation

Children’s Oncology Group recommended surveillance for survivors at high risk

Annual mammogram/MRI beginning 8 years after radiation or age 25 years, whichever occurs last

Colonoscopy every 5 years beginning at age 35 years

Echocardiogram or MUGA

Annually if anthracycline ≥300 mg/m²

q 2 years if anthracycline 200–300 mg/m² OR anthracycline <300 mg/m² + radiation q 5 years if anthracycline <200 mg/m², no radiation