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Table 2 Clinicopathological characteristics according to PI3K/RAS-RAF pathway gene mutation status in 214 (212) colorectal cancer patients

From: BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

  

KRAS exon 2

BRAF exon 15

PIK3CA exon 9&20*

PI3K/RAS-RAF pathway*

  

No. patients (214/212)

No (%)

Yes (%)

P

No (%)

Yes (%)

P

No (%)

Yes (%)

P

No (%)

Yes (%)

P

Sex

male

127 (126)

73 (61.9)

54 (56.3)

0.406a

122 (59.5)

5 (55.6)

1.000b

109 (58.6)

17 (65.4)

0.509a

60 (61.2)

66 (57.9)

0.623a

 

female

87 (86)

45 (38.1)

42 (43.8)

 

83 (40.5)

4 (44.4)

 

77 (41.4)

9 (34.6)

 

38 (38.8)

48 (42.1)

 

Age

 

68.0

67.1

69.1

0.286d

68.0

66.9

0.801d

68.7

64.6

0.133d

67.8

68.4

0.728d

Location

colon

126 (124)

73 (61.9)

53 (55.2)

0.325a

117 (57.1)

9 (100.0)

0.011 b

103 (55.4)

21 (80.8)

0.014 a

54 (55.1)

70 (61.4)

0.353a

 

rectum

88 (88)

45 (38.1)

43 (44.8)

 

88 (42.9)

0 (0)

 

83 (44.6)

5 (19.2)

 

44 (44.9)

44 (38.6)

 

Differentiation

well

29 (29)

19 (16.1)

10 (10.4)

0.912c

28 (13.7)

1 (11.1)

0.131c

22 (11.8)

7 (26.9)

0.215c

15 (15.3)

14 (12.3)

0.521c

 

moderate

163 (161)

83 (70.3)

80 (83.3)

 

159 (77.6)

4 (44.4)

 

145 (78.0)

16 (61.5)

 

73 (74.5)

88 (77.2)

 
 

poor

7 (7)

7 (5.9)

0 (0)

 

5 (2.4)

2 (22.2)

 

5 (2.7)

2 (7.7)

 

3 (3.1)

4 (3.5)

 
 

missing

15 (15)

9 (7.6)

6 (6.3)

 

13 (6.3)

2 (22.2)

 

14 (7.5)

1 (3.8)

 

7 (7.1)

8 (7.0)

 

Tumor diameter

<5 cm

103 (102)

53 (44.9)

50 (52.1)

0.254c

101 (49.3)

2 (22.2)

0.171b

93 (50.0)

9 (34.6)

0.172a

46 (46.9)

56 (49.1)

0.710a

 

> = 5 cm

108 (107)

64 (54.2)

44 (45.8)

 

101 (49.3)

7 (77.8)

 

91 (48.9)

16 (61.5)

 

51 (52.0)

56 (49.150.0)

 
 

missing

3 (3)

1 (0.8)

2 (2.1)

 

3 (1.5)

0 (0)

 

2 (1.1)

1 (3.8)

 

1 (1.0)

2 (1.8)

 

TNM-stage

I

32 (32)

15 (12.7)

17 (17.7)

0.828c

32 (15.6)

0 (0)

0.007 c

26 (14.0)

6 (23.1)

0.433c

13 (13.3)

19 (16.7)

0.231c

 

II

78 (77)

50 (42.4)

28 (29.2)

 

76 (37.1)

2 (22.2)

 

69 (37.1)

8 (30.8)

 

44 (44.9)

33 (28.9)

 
 

III

82 (81)

38 (32.2)

44 (45.8)

 

79 (38.5)

3 (33.3)

 

70 (37.6)

11 (42.3)

 

31 (31.6)

50 (43.9)

 
 

IV

19 (19)

13 (11.0)

6 (6.3)

 

15 (7.3)

4 (44,4)

 

18 (9.7)

1 (3.8)

 

8 (8.2)

11 (9.6)

 
 

missing

3 (3)

2 (1.7)

1 (1.0)

 

3 (1.5)

0 (0)

 

3 (1.6)

0 (0)

 

2 (2.0)

1 (0.9)

 

T

T1

5 (5)

4 (3.4)

1 (1.0)

0.236c

5 (2.4)

0 (0)

0.057c

5 (2.7)

0 (0)

0.808c

4 (4.1)

1 (0.9)

0.724c

 

T2

35 (35)

15 (12.7)

20 (20.8)

 

35 (17.1)

0 (0)

 

29 (15.6)

6 (23.1)

 

13 (13.3)

22 (19.3)

 
 

T3

167 (166)

93 (78.8)

74 (77.1)

 

159 (77.6)

8 (88.9)

 

147 (79.0)

19 (73.1)

 

77 (78.6)

89 (78.1)

 
 

T4

5 (4)

4 (3.4)

1 (1.0)

 

4 (2.0)

1 (11.1)

 

3 (1.6)

1 (3.8)

 

2 (2.0)

2 (1.8)

 
 

missing

2 (2)

2 (1.7)

0 (0)

 

2 (1.0)

0 (0)

 

2 (1.1)

0 (0)

 

2 (2.0)

0 (0)

 

N

N(−)

115 (114)

70 (59.3)

45 (46.9)

0.050 a

113 (55.1)

2 (22.2)

0.083b

99 (53.2)

15 (57.7)

0.710a

61 (62.2)

53 (46.5)

0.013 a

 

N(+)

97 (96)

46 (39.0)

51 (53.1)

 

90 (43.9)

7 (77.8)

 

85 (45.7)

11 (42.3)

 

35 (35.7)

61 (53.5)

 
 

missing

2 (2)

2 (1.7)

0 (0)

 

2 (1.0)

0 (0)

 

2 (1.1)

0 (0)

 

2 (2.0)

0 (0)

 

Metastases

M(−)

163 (161)

88 (74.6)

75 (78.1)

0.367a

159 (77.6)

4 (44.4)

0.037 b

144 (77.4)

17 (65.4)

1.808a

77 (78.6)

84 (73.7)

0.689a

 

M(+)

51 (51)

30 (25.4)

21 (21.9)

 

46 (22.4)

5 (55.6)

 

42 (22.6)

9 (34.6)

 

21 (21.4)

30 (26.3)

 

Synchronous metastases

M(−)

193 (191)

104 (88.1)

89 (92.7)

0.224a

188 (91.7)

5 (55.6)

0.004 b

166 (89.2)

25 (96.2)

0.479b

89 (90.8)

102 (89.5)

0.708a

 

M(+)

19 (19)

13 (11.0)

6 (6.3)

 

15 (7.3)

4 (44.4)

 

18 (9.7)

1 (3.8)

 

8 (8.2)

11 (9.6)

 
 

missing

2 (2)

1 (0.8)

1 (1.0)

 

2 (1.0)

0 (0)

 

2 (1.1)

0 (0)

 

1 (1.0)

1 (1.0)

 

Metachronous metastases

M(−)

176 (174)

95 (80.5)

81 (84.4)

0.462a

171 (83.4)

5 (55.6)

0.055b

156 (83.9)

18 (69.2)

0.097b

82 (83.7)

92 (80.7)

0.574a

 

M(+)

38 (38)

23 (19.5)

15 (15.6)

 

34 (16.6)

4 (44.4)

 

30 (16.1)

8 (30.8)

 

16 (16.3)

22 (19.3)

 
  1. achi-square test; bFisher exact test; cMann–Whitney test; dt test; *DNA of two samples were not available for PIK3CA exon 20. P-values ≤ 0.05 are in bold.