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Table 4 IPA based experimentally observed information for differentially expressed miRNAs and differential expression (FC > ±1.5) of their regulated mRNA targets in HGSC

From: Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker

miRNAs mRNA targets Cancer association OC association
miR-134↓   x  
miR-141-3p↑ TGFB2, ZEB2, JAG1, BAP1, CLOCK, ELMO2, ERBB2IP, KLHL20, MAP2K4, PLCG1, PTPRD, WDR37 x x (EC)
miR-182-5p↑ FOXO3, ADCY6, CASP2, CLDN17, NCAM1, NFASC, RARG, BCL2L14, CARD11, CASP10, CASP12, CDH1, CDH4, CDK6, CLDN15, COL11A2, COL4A4, FNDC3A, FOXO1, GADD45G, GJA3, IGF1R, INHBC, ITGA4, LRP6, MALAT1, MITF, MTSS1, NLGN2, PGF, PIK3CA, RPS6KB1, SOS1, VWF x x (EC)
miR-200a-3p↑ CTNNB1, VIM, ZEB1, ZEB2, BAP1, CDK6, CDKN1B, CTBP2, CYP1B1↑, ELMO2, ERBB2IP, KLHL20, PLCG1, PTPRD, TUBB, WDR37, ZFPM2 x x (EC, ROC)
miR-200a-5p↑   x  
miR-200b-3p↑ VIM, ZEB1, ZEB2, BAP1, ELMO2, ERBB2IP, ERRFI1, KLHL20, PLCG1, PTPRD, RERE, WASF3, WDR37, ZFPM2 x x (ROC)
miR-200c-3p↑ CDH1, PTPN13, ZEB1, ZEB2, FHOD1, PPM1F, JAG1, MARCKS, VIM, CDKN1B, ERRFI1, PLCG1 x x (EC)
miR-202-3p↓    
miR-205-5p↑ ERBB3, F Actin, INPPL1, MED1, VEGFA, ZEB1, ZEB2, PRKCE x x (EC)
miR-383↓    
miR-424-5p↓ FGFR1, MAP2K1, NFIA, PLAG1 x  
miR-508-5p    
miR-509-3p↓ NTRK3   
miR-509-5p↓    
miR-509-3-5p↓    
miR-510↓ HTR3E, SPDEF x  
miR-513a-5p CD274 x  
miR-514b-5p↓    
  1. IPA: Ingenuity Pathway Analysis. HGSC: High-grade serous ovarian carcinoma. OC: Ovarian carcinoma. EC: Endometrioid OC. ROC: Recurrent OC. Over- and underexpressed miRNAs (based on Tables 2 and 3) and mRNAs (based on global gene expression analysis [29]) in HGSC vs. ovarian surface epithelium (OSE) are indicated by upward and downward arrows, respectively. A complete list of HGSC vs. OSE FC values for the mRNA targets is available in Additional file 2.