Figure 4

Differentially expressed (FC ≥ 2) miRNAs in HGSC targeting a HGSC molecular pathway of differentially expressed mRNAs [29]. Calculated differential expression is between high-grade serous ovarian carcinomas (HGSC) and ovarian surface epithelium, for miRNAs based on global gene expression analysis (ANOVA, FDR < 5) and for mRNAs based on RT-qPCR analyses [29]. → acts on (— direct interaction, -- indirect interaction), ⟂ inhibits. FC: Fold change. EO: Experimentally observed interactions. HP: Interactions of high predicted confidence. MP: Interactions of moderate predicted confidence. The abbreviations of the miRNA-mRNA interactions are generally placed after the miRNA FC values, but are placed on the arrow of the miRNA-mRNA interaction for miRNAs having several targets with different interaction type. Results were generated through Ingenuity Pathway Analysis.