|
Cohort I
|
% of patients with different expression levels
| |
Cohort II
|
% of patients with different expression levels
| |
---|
|
N
|
Neg
|
Weak
|
Moderate
|
Strong
|
p-value
|
N
|
Neg
|
Weak
|
Moderate
|
Strong
|
p-value
|
---|
Total
|
264
|
11
|
32
|
43
|
14
| |
206
|
2
|
30
|
58
|
10
| |
Age
| | | | | | | | | | | | |
Median age
|
264
|
63a
|
61a
|
63a
|
60a
|
0.34b
|
206
|
45a
|
46a
|
47a
|
47a
|
0.026b
|
Menopausal status
| | | | | | | | | | | | |
Pre
|
55
|
7
|
29
|
45
|
18
|
0.15c
|
n/a
| | | | | |
Post
|
209
|
12
|
33
|
43
|
12
| | | | | | | |
Tumor size
| | | | | | | | | | | | |
0 – 20 mm
|
78
|
8
|
35
|
50
|
8
|
0.83c
|
156
|
3
|
30
|
58
|
10
|
0.74c
|
>20 mm
|
186
|
13
|
31
|
40
|
16
| |
50
|
2
|
28
|
60
|
10
| |
Node status
| | | | | | | | | | | | |
N0
|
86
|
12
|
35
|
41
|
13
|
0.52c
|
n/a
| | | | | |
N+
|
178
|
11
|
30
|
44
|
14
| | | | | | | |
NHG
| | | | | | | | | | | | |
1 – 2
|
186
|
8
|
32
|
45
|
15
|
0.086c
|
138
|
1
|
29
|
62
|
9
|
0.39c
|
3
|
75
|
19
|
31
|
39
|
12
| |
66
|
6
|
32
|
50
|
12
| |
Missing
|
3
| | | | | |
2
| | | | | |
ER
| | | | | | | | | | | | |
Positive
|
174
|
3
|
29
|
49
|
18
|
<0.001c
|
139
|
1
|
27
|
63
|
9
|
0.32c
|
Negative
|
80
|
29
|
38
|
29
|
5
| |
67
|
4
|
34
|
49
|
12
| |
Missing
|
10
| | | | | |
0
| | | | | |
PgR
| | | | | | | | | | | | |
Positive
|
133
|
2
|
29
|
52
|
17
|
<0.001c
|
149
|
1
|
28
|
63
|
7
|
0.66c
|
Negative
|
121
|
21
|
34
|
33
|
12
| |
57
|
5
|
33
|
46
|
16
| |
Missing
|
10
| | | | | |
0
| | | | | |
Ki67
| | | | | | | | | | | | |
Low
|
162
|
8
|
33
|
43
|
16
|
0.095c
|
125
|
2
|
32
|
59
|
7
|
0.33c
|
High
|
99
|
17
|
29
|
43
|
10
| |
61
|
3
|
28
|
52
|
16
| |
Missing
|
3
| | | | | |
20
| | | | | |
HER2
| | | | | | | | | | | | |
Negative
|
199
|
9
|
32
|
44
|
15
|
0.042c
|
171
|
1
|
29
|
60
|
9
|
0.027c
|
Positive
|
33
|
21
|
33
|
39
|
6
| |
22
|
14
|
41
|
36
|
9
| |
Missing
|
32
| | | | | |
13
| | | | | |
St Gallen subgroups
d
| | | | | | | | | | | | |
Luminal A-like
|
72
|
4
|
32
|
46
|
18
|
<0.001e
|
92
|
0
|
27
|
64
|
9
|
0.24e
|
Luminal B-like
|
80
|
4
|
26
|
51
|
19
| |
32
|
3
|
31
|
53
|
13
| |
Triple-negative
|
42
|
26
|
43
|
26
|
5
| |
32
|
3
|
41
|
41
|
16
| |
HER2+ (non-luminal)
|
18
|
39
|
33
|
22
|
6
| |
8
|
25
|
38
|
25
|
13
| |
Missing
|
52
| | | | | |
42
| | | | | |
- Abbreviations: ER = Estrogen receptor, PgR = Progesterone receptor, HER2 = Human epidermal growth factor receptor 2, NHG = Histological grade according to Elston and Ellis [35], n/a = Not applicable.
-
aMedian age in the different groups.
-
bSpearman’s rank-correlation.
-
cMann–Whitney test.
-
dSee (34) for complete definition of St Gallen subgroups.
-
eKruskal-Wallis test.