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Table 1 Cytoplasmic intensity of IGF1R expression in relation to tumor and patient characteristics for Cohort I (N = 264) and Cohort II (N = 206)

From: Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer

  Cohort I % of patients with different expression levels   Cohort II % of patients with different expression levels  
  N Neg Weak Moderate Strong p-value N Neg Weak Moderate Strong p-value
Total 264 11 32 43 14   206 2 30 58 10  
Age             
Median age 264 63a 61a 63a 60a 0.34b 206 45a 46a 47a 47a 0.026b
Menopausal status             
Pre 55 7 29 45 18 0.15c n/a      
Post 209 12 33 43 12        
Tumor size             
0 – 20 mm 78 8 35 50 8 0.83c 156 3 30 58 10 0.74c
>20 mm 186 13 31 40 16   50 2 28 60 10  
Node status             
N0 86 12 35 41 13 0.52c n/a      
N+ 178 11 30 44 14        
NHG             
1 – 2 186 8 32 45 15 0.086c 138 1 29 62 9 0.39c
3 75 19 31 39 12   66 6 32 50 12  
Missing 3       2      
ER             
Positive 174 3 29 49 18 <0.001c 139 1 27 63 9 0.32c
Negative 80 29 38 29 5   67 4 34 49 12  
Missing 10       0      
PgR             
Positive 133 2 29 52 17 <0.001c 149 1 28 63 7 0.66c
Negative 121 21 34 33 12   57 5 33 46 16  
Missing 10       0      
Ki67             
Low 162 8 33 43 16 0.095c 125 2 32 59 7 0.33c
High 99 17 29 43 10   61 3 28 52 16  
Missing 3       20      
HER2             
Negative 199 9 32 44 15 0.042c 171 1 29 60 9 0.027c
Positive 33 21 33 39 6   22 14 41 36 9  
Missing 32       13      
St Gallen subgroups d             
Luminal A-like 72 4 32 46 18 <0.001e 92 0 27 64 9 0.24e
Luminal B-like 80 4 26 51 19   32 3 31 53 13  
Triple-negative 42 26 43 26 5   32 3 41 41 16  
HER2+ (non-luminal) 18 39 33 22 6   8 25 38 25 13  
Missing 52       42      
  1. Abbreviations: ER = Estrogen receptor, PgR = Progesterone receptor, HER2 = Human epidermal growth factor receptor 2, NHG = Histological grade according to Elston and Ellis [35], n/a = Not applicable.
  2. aMedian age in the different groups.
  3. bSpearman’s rank-correlation.
  4. cMann–Whitney test.
  5. dSee (34) for complete definition of St Gallen subgroups.
  6. eKruskal-Wallis test.