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Table 1 Characteristics of study sample by treatment group

From: Does the time between CT scan and chemotherapy increase the risk of acute adverse reactions to iodinated contrast media in cancer patients?

 

Platinum

Taxane

Platinum plus Taxane

Other

P

Contrast-enhanced CTs, n

1249

385

182

2129

 

Median duration of treatment, d [range]

70 [1–502]

77 [1–483]

50 [1–258]

73 [1–707]

< 0.0001

Mean no. of CTs per patient (SD)

1.72 (1.07)

2.18 (1.59)

1.55 (0.78)

2.42 (1.82)

< 0.0001

Median patient age at CT, y [range]

65 [18–87]

64 [23–86]

61 [23–80]

66 [21–91]

< 0.0001

Primary tumor

     

   Gastrointestinal

618 (49.5%)

12 (3.1%)

27 (14.8%)

541 (25.4%)

< 0.0001

   Urogynecological

160 (12.8%)

129 (33.5%)

115 (63.2%)

266 (12.5%)

 

   Breast

47 (3.8%)

176 (45.7%)

8 (4.4%)

523 (24.6%)

 

   Lung

305 (24.4%)

50 (13%)

10 (5.5%)

271 (12.7%)

 

   Hematological

6 (0.5%)

1 (0.3%)

2 (1.1%)

207 (9.7%)

 

   Melanoma

44 (3.5%)

-

5 (2.8%)

128 (6%)

 

   Other sites

69 (5.5%)

17 (4.4%)

15 (8.2%)

193 (9.1%)

 

ICM-related ARs, n (%)

9 (0.7)

5 (1.3)

4 (2.2)

22 (1.0)*

0.221

  1. Abbreviations: Other, any chemotherapy without platinum or taxane; n number, d days, y years, CT computed tomography, SD standard deviation, ICM iodinated contrast media, AR adverse reaction.
  2. *4 ARs with vinca alkaloid-based therapy; 3 with anthracycline-based therapy; 3 with fluorouracil-based therapy; 3 with tyrosine kinase inhibitors; 2 with IL2; 2 with gemcitabine; 1 with irinotecan; 1 with fotemustine; 1 with bevacizumab; 1 with interferon; 1 with ipilimumab.