Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins

Table 2 Relationship between known prognostic factors and CXCL1 protein expression in breast cancer stroma

Factor	r	95% CI	p-value	n
Age	0.12	-0.03 to 0.40	0.08	79
tumor size	0.18	-0.11 to 0.44	0.19	51
BCL2	-0.06	-0.40 to 0.29	0.72	34
P53	0.08	-0.23 to 0.38	0.60	43
Ki67	0.25	-0.07 to 0.51	0.12	41
ER	-0.07	-0.37 to 0.24	0.70	42
PR	0.10	-0.22 to 0.40	0.51	42
HER2	0.14	-0.19 to 0.44	0.40	40
EGFR	0.07	-0.26 to 0.39	0.63	38
No. of lymph node metastases	0.17	-0.14 to 0.45	0.28	23

Association between CXCL1 protein expression and commonly used prognostic markers was determined in DCIS and IDC stromal tissues using Spearman Correlation analysis. Significance was determined by p<0.05. r= correlation coefficient.

ISSN: 1471-2407