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Table 2 Results of subgroup analyses on RFS and OS

From: Meta-analysis shows that circulating tumor cells including circulating microRNAs are useful to predict the survival of patients with gastric cancer

Variables

RFS

OS

 

HR[95%CI]

n

I2

Pd

HR[95%CI]

n

I2

Pd

Year > median a

        

No

2.45[1.13-5.31]

4

78.87%

0.003

1.82[1.34-2.46]

15

45.79%

0.027

Yes

3.02[2.18-4.18]

6

0.00%

0.519

1.72[1.46-2.04]

15

0.00%

0.479

Country

        

East Asia

2.93[1.67-5.14]

7

66.13%

0.007

1.76[1.50-2.07]

21

18.48%

0.220

Non-East Asia

2.62[1.35-5.10]

3

0.00%

0.596

1.41[1.22-1.63]

9

39.70%

0.103

Methodology

        

Cytological

3.71[1.95-7.06]

2

42.92%

0.186

1.77[1.16-2.70]

5

54.00%

0.069

Molecular

2.64[1.52-4.59]

8

57.03%

0.023

1.54[1.37-1.72]

25

26.23%

0.114

Approach

        

RT-PCR

2.61[1.52-4.59]

8

57.04%

0.023

1.79[1.46-2.20]

24

29.30%

0.090

CellSearch

3.71[1.95-7.01]

2

42.92%

0.186

2.00[1.28-3.13]

3

64.90%

0.058

Others

/

/

/

/

1.04[0.46-2.34]

3

0.00%

0.564

Marker type

        

Non-miRNA

3.08[1.80-5.26]

9

56.48%

0.019

1.80[1.45-2.25]

22

41.33%

0.023

miRNA

/

/

/

/

1.70[1.33-2.16]

8

0.00%

0.602

Time point

        

Pre-therapy

3.45[2.54-4.67]

7

0.00%

0.529

1.81[1.54-2.13]

23

28.58%

0.100

Intra/post-therapy

1.09[0.25-4.73]

3

69.09%

0.039

1.38[1.19-1.60]

7

0.00%

0.539

Patient no. > median b

        

No

2.40[1.24-4.65]

5

71.90%

0.007

1.73[1.44-2.08]

18

9.70%

0.339

Yes

3.24[2.26-4.66]

5

0.00%

0.482

1.82[1.37-2.42]

12

47.91%

0.032

Detection rate > median c

        

No

2.69[1.33-5.44]

5

74.38%

0.004

1.75[1.42-2.15]

14

33.73%

0.105

Yes

2.82[1.87-4.27]

5

0.00%

0.524

1.49[1.31-1.70]

16

27.31%

0.149

Overall

2.91[1.84-4.61]

10

52.18%

0.027

1.78[1.49-2.12]

30

30.71%

0.058

  1. aThe median year for both RFS and OS was 2010.
  2. bThe median patient no. per study for RFS and OS was 59 and 65, respectively.
  3. cThe median detection rate for RFS and OS was 46.05% and 51.55%, respectively.
  4. dTwo-tailed P value of tests for heterogeneity.