Variables | RFS | OS | ||||||
---|---|---|---|---|---|---|---|---|
 | HR[95%CI] | n | I2 | Pd | HR[95%CI] | n | I2 | Pd |
Year > median a |  |  |  |  |  |  |  |  |
No | 2.45[1.13-5.31] | 4 | 78.87% | 0.003 | 1.82[1.34-2.46] | 15 | 45.79% | 0.027 |
Yes | 3.02[2.18-4.18] | 6 | 0.00% | 0.519 | 1.72[1.46-2.04] | 15 | 0.00% | 0.479 |
Country | Â | Â | Â | Â | Â | Â | Â | Â |
East Asia | 2.93[1.67-5.14] | 7 | 66.13% | 0.007 | 1.76[1.50-2.07] | 21 | 18.48% | 0.220 |
Non-East Asia | 2.62[1.35-5.10] | 3 | 0.00% | 0.596 | 1.41[1.22-1.63] | 9 | 39.70% | 0.103 |
Methodology | Â | Â | Â | Â | Â | Â | Â | Â |
Cytological | 3.71[1.95-7.06] | 2 | 42.92% | 0.186 | 1.77[1.16-2.70] | 5 | 54.00% | 0.069 |
Molecular | 2.64[1.52-4.59] | 8 | 57.03% | 0.023 | 1.54[1.37-1.72] | 25 | 26.23% | 0.114 |
Approach | Â | Â | Â | Â | Â | Â | Â | Â |
RT-PCR | 2.61[1.52-4.59] | 8 | 57.04% | 0.023 | 1.79[1.46-2.20] | 24 | 29.30% | 0.090 |
CellSearch | 3.71[1.95-7.01] | 2 | 42.92% | 0.186 | 2.00[1.28-3.13] | 3 | 64.90% | 0.058 |
Others | / | / | / | / | 1.04[0.46-2.34] | 3 | 0.00% | 0.564 |
Marker type | Â | Â | Â | Â | Â | Â | Â | Â |
Non-miRNA | 3.08[1.80-5.26] | 9 | 56.48% | 0.019 | 1.80[1.45-2.25] | 22 | 41.33% | 0.023 |
miRNA | / | / | / | / | 1.70[1.33-2.16] | 8 | 0.00% | 0.602 |
Time point | Â | Â | Â | Â | Â | Â | Â | Â |
Pre-therapy | 3.45[2.54-4.67] | 7 | 0.00% | 0.529 | 1.81[1.54-2.13] | 23 | 28.58% | 0.100 |
Intra/post-therapy | 1.09[0.25-4.73] | 3 | 69.09% | 0.039 | 1.38[1.19-1.60] | 7 | 0.00% | 0.539 |
Patient no. > median b | Â | Â | Â | Â | Â | Â | Â | Â |
No | 2.40[1.24-4.65] | 5 | 71.90% | 0.007 | 1.73[1.44-2.08] | 18 | 9.70% | 0.339 |
Yes | 3.24[2.26-4.66] | 5 | 0.00% | 0.482 | 1.82[1.37-2.42] | 12 | 47.91% | 0.032 |
Detection rate > median c |  |  |  |  |  |  |  |  |
No | 2.69[1.33-5.44] | 5 | 74.38% | 0.004 | 1.75[1.42-2.15] | 14 | 33.73% | 0.105 |
Yes | 2.82[1.87-4.27] | 5 | 0.00% | 0.524 | 1.49[1.31-1.70] | 16 | 27.31% | 0.149 |
Overall | 2.91[1.84-4.61] | 10 | 52.18% | 0.027 | 1.78[1.49-2.12] | 30 | 30.71% | 0.058 |