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Table 1 The 23 CpG units showing area under the curve (AUC) values larger than 0.95 in receiver operating characteristic curve analysis for discrimination of CpG island methylator phenotype (CIMP)-positive clear cell renal cell carcinomas (ccRCCs) from CIMP-negative ccRCCs in the learning cohort

From: Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes

ID of CpG unit1

Gene symbol

Chromo-

some

Position of CpG site2

AUC value

Cutoff value3(%)

Sensitivity4

(%)

Specificity4

(%)

81

TRH

3

129693406, 129693412

0.973

30.8

100.0

88.6

85

TRH

3

129693518, 129693521, 129693528

0.950

18.2

100.0

78.4

89

TRH

3

129693586

0.952

11.0

92.3

92.0

94

TRH

3

129693635

0.967

6.6

100.0

87.5

8

FAM150A

8

53478477

0.968

27.2

83.3

94.1

11

FAM150A

8

53478511

0.968

27.2

83.3

94.1

78

PRAC

17

46799755

0.957

40.7

92.9

89.8

102

SLC13A5

17

6616733

0.983

7.5

92.9

96.6

105

SLC13A5

17

6616812

0.983

18.5

100.0

94.3

106

SLC13A5

17

6616826, 6616828

0.951

23.3

100.0

88.6

107

SLC13A5

17

6616851, 6616854, 6616857

0.954

14.8

100.0

87.5

110

SLC13A5

17

6616927, 6616929

0.951

23.3

100.0

88.6

30

ZNF540

19

38042496

0.983

41.0

100.0

98.3

32

ZNF540

19

38042518

0.960

35.7

100.0

93.1

33

ZNF540

19

38042530, 38042532

0.991

36.4

100.0

96.6

43

ZNF154

19

58220567

0.956

13.3

92.9

90.9

44

ZNF154

19

58220627

0.966

14.8

85.7

95.5

45

ZNF154

19

58220657, 58220662

0.959

22.2

92.9

95.5

149

ZNF671

19

58238780

0.954

15.2

85.7

89.7

158

ZNF671

19

58238928

0.965

10.5

100.0

88.5

160

ZNF671

19

58238954

0.954

15.2

85.7

89.7

161

ZNF671

19

58238987

0.954

15.2

85.7

89.7

163

ZNF671

19

58239012

0.951

10.5

85.7

92.0

  1. 1ID of CpG unit is defined in Additional file 4: Table S4.
  2. 2National Center for Biotechnology Information (NCBI) Database (Genome Build 37).
  3. 3The Youden index was used as a cutoff value for discriminating CIMP-positive ccRCCs in the learning cohort from CIMP-negative ccRCCs. When the cancerous tissue shows a DNA methylation level equal to or higher than the cutoff value, the ccRCC is considered to be CIMP-positive; when the cancerous tissue shows a DNA methylation level lower than the cutoff value, the ccRCC is considered to be CIMP-negative.
  4. 4Sensitivity and specificity for discrimination of CIMP-positive ccRCCs in the learning cohort from CIMP-negative ccRCCs using individual CpG units.