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Figure 1 | BMC Cancer

Figure 1

From: Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes

Figure 1

Average DNA methylation levels at promoter CpG islands in the SLC13A5 (A) and ZNF671 (B) genes in CIMP-negative (n = 88) and CIMP-positive (n = 14) ccRCCs in the learning cohort. DNA methylation levels of each CpG unit were evaluated quantitatively using the MassARRAY system. A. Average DNA methylation levels of all examined 38 CpG units including 68 CpG sites located within 1347 bp 5′ region of the SLC13A5 gene in CIMP-positive ccRCCs (red line) were significantly higher than those in CIMP-negative ccRCCs (blue line). B. Average DNA methylation levels of all examined 21 CpG units including 29 CpG sites located within the 428 bp 5′ region of the ZNF671 gene in CIMP-positive ccRCCs (red line) were significantly higher than those in CIMP-negative ccRCCs (blue line). *P < 0.05 and **P < 0.01. Exact P values for each CpG unit of the SLC13A5 and ZNF671 genes are summarized in Additional file 7: Table S5. Error bar: standard error.

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