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Table 3 Clinical outcomes of CRC patients with MTB or MK infection

From: Comparison of the clinical courses and chemotherapy outcomes in metastatic colorectal cancer patients with and without active Mycobacterium tuberculosis or Mycobacterium kansasiiinfection: a retrospective study

Patient

Diagnosis method for MTB or MK infection

Treatment of MTB or MK

Time from the beginning of MTB or MK therapy until the start of first-line chemotherapy (days)

MTB or MK treatment success

A

CT imaging

6HRE/6HR

16

Completion

B

Sputum TB-PCR (+), MTB culture (+)

2HREZ/7HR

104

Cure

C

Sputum smear (+), MTB culture (+)

24HE

408

Cure

D

Sputum smear (+), MK culture (+)

18HRE

56

Cure

E

Sputum smear (-), MTB culture (+)

9HRE

25

Cure

F

Sputum smear (-), Sputum TB-PCR (+), MTB culture (+)

6HRE/6HR

19

Cure

G

Sputum smear (+), MTB culture (+)

12RE

53

Cure

Patient

First-line chemotherapy Regimen

Best response

Side effects (grade ≥ 3) due to cancer chemotherapy or MTB or MK treatment

A

UFT/LV

SD

-

B

FOLFOX6 + Cmab

CR

-

C

FOLFOX6

PD

Liver dysfunction due to MTB treatment

D

FOLFOX6 + Pmab

PD

-

E

FOLFOX6 + Bmab

SD

Hemoptysis due to Bmab

F

FOLFOX6

PR

-

G

FOLFIRI

PD

-

  1. MTB: Mycobacterium tuberculosis, MK: Mycobacterium kansasii, CT: computed tomography, TB-PCR: tuberculosis polymerase chain reaction.
  2. H: isoniazid, R: rifampicin, E: ethambutol, Z: pyrazinamide.
  3. nHREZ: n months of H, R, E and Z combination.
  4. CR: complete response, PR: partial response, SD: stable disease, PD: progression disease.
  5. FOLFOX: folinic acid, fluorouracil, oxaliplatin, Bmab: bevacizumab, FOLFIRI: folinic acid, fluorouracil, irinotecan, Pmab: panitumumab, Cmab: cetuximab, XELOX: capecitabine plus oxaliplatin, UFT/LV: uracil/tegafur/leucovorin.