Figure 3

Analysis of FAK expression in primary tumors and matched metastatic tissues. A. Distribution of FAK expression in 117 primary and matched metastatic tissues. Upper and lower panels show distribution of FAK expression in primary and metastatic tissues (N = 117). The median FAK expression in primary tumors is equal to 3.5 and in metastatic tissues 2.67 (N = 117). Normal (marked by solid line) and Kernel (marked by dotted line) distribution of FAK expression in both groups are shown. Wilcoxon Exact p-value = 0.024. B. Correlation between FAK expression in primary and metastatic tissues. The positive Spearman correlation between FAK expression is shown. Correlation coefficients are shown on left lower panel. C. Overall survival and progression free survival in patients with matched primary and metastatic breast cancer tumors. Left panels: Progression-free survival and overall survival (OS) curves in patients with primary tumors with high FAK (FAK > 4) compared to low FAK expression (FAK ≤ 4). Right panels: Progression-free survival curve and overall survival curves in patients with metastatic tumors. There is a strong correlation between high FAK expression in metastatic tumors and shorter PFS and OS. Logrank p < 0.05.