TY - JOUR AU - Wang, Jing AU - Gu, Song AU - Huang, Jun AU - Chen, Sheng AU - Zhang, Zhen AU - Xu, Min PY - 2014 DA - 2014/10/17 TI - Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells JO - BMC Cancer SP - 768 VL - 14 IS - 1 AB - Aberrant Hedgehog (Hh) signaling is often associated with neuroblastoma (NB), a childhood malignancy with varying clinical outcomes due to different molecular characteristics. Inhibition of Hh signaling with small molecule inhibitors, particularly with GANT-61, significantly suppresses NB growth. However, NB with MYCN amplification is less sensitive to GANT-61 than those without MYCN amplification. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-14-768 DO - 10.1186/1471-2407-14-768 ID - Wang2014 ER -