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Table 1 Results of mutation analysis

From: Chemically induced mouse liver tumors are resistant to treatment with atorvastatin

Mutation/AA exchange

No. of tumors

Ha-ras Cod. 61 Q âž” R

7

Ha-ras Cod. 61 Q âž” L

1

Ha-ras Cod. 61 Q âž” K

4

Ha-ras Cod. 61 Q âž” H

0

B-raf Cod. 637 V ➔ E

8

None detected

6

  1. In total, 26 tumors were analyzed for mutations in Ha-ras or B-raf.
  2. Note: The absence of Ha-ras or B-raf mutations in a tumor does not preclude activation of MAPK signaling in this tumor driven by other genetic alterations.
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BMC Cancer

ISSN: 1471-2407

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