Figure 4

Lack of atorvastatin effects on the growth of N-nitrosodiethylamine-induced mouse liver tumors. A. Tumor volume fraction of control and atorvastatin-treated mice, as quantified by the analysis of glucose-6-phosphatase-altered lesion. B. Projected tumor multiplicity. Individual data from n = 24-25 mice per group are shown together with the corresponding box charts. C. Distribution of tumor volume fraction between mice from the two groups. Mice were grouped into the following responder classes according to their hepatic tumor volume fractions: I, tumor volume fraction <10%; II, 10-15%; III, 15.01-20%; IV, 20.01-25%; V, 25.01-30%; VI, 30.01-35%; VII, 35.01-40%; VIII, 40.01-45%; IX, 45.01-50%; X, 50.01-60%; XI, >60%. The atorvastatin group has a higher percentage of weak responders (class I), but also a higher percentage of strong responders (classes X and XI). D. Size class distribution of tumor multiplicity. Tumors were grouped into the following size classes: I, 0.05-0.25 mm diameter; II, 0.26-0.5 mm; III, 0.51-1.00 mm; IV, 1.01-2.00 mm; V, 2.01-6.5 mm; VI, >6.5 mm. Mean + SEM (n = 24-25) is shown. Statistical significance (p < 0.05) is indicated by asterisks. Very big tumors are exclusively observed in the atorvastatin group.