Figure 4

Network-based analysis of MDA-MB-231 25PACR, ZR75-1 25PACR and ZR75-1 25DOCR taxane resistant cell lines. A. Venn diagram of genes within significant areas of gain. B. Venn diagram of genes within significant areas of loss in 3 cell lines. C. Mitotic prometaphase module identified from functional interaction network analysis. D. Bar graph shows relative expression levels of AHCTH1, CENPF, PPP2R5A, NUP133, MLP1P and NSL1 in the MDA-MB-231 native, 25PACR, 50 PACR ZR75-1 25PACR, 50PACR and ZR75-1 25DOCR and 50DOCR taxane resistant cell lines. Error bars show standard deviation of three experiments. Asterisks indicate statistical difference * = p < 0.05, ** = p < 0.001.