Figure 3

aCGH of taxane resistant cell lines. The plots show Log2Ratios of test to reference signal intensity from BAC clines in an aCGH experiment using DNA from native cells as a reference samples and DNA from resistant cells as a test sample. Navy dots represent BAC clones which remain unchanged, the green dots represent the BAC clones in which there is an area of gain on the genome, and the red dots represent the BAC clones in which there is an area of loss of the genome. The Log2ratio is measured on the Y axis and on the X axis the genome runs in chromosome order from 1 to the sex chromosomes. The p or short arm on each chromosome is followed by the q or long arm. The dotted lines represent the position of the centromere. The cbs algorithm recursively split chromosomes into segments based on the maximum t statistic estimated by each permutation (re Mathworks.com). A. MDA-MB-231 Natives vs MDA-MB-231 25PACR. B. MDA-MB-231 Natives vs MDA-MB-231 50PACR. C. ZR75-1 native cells vs ZR75-1 25PACR. D. ZR75-1 native cells vs ZR75-1 50PACR. E. ZR75-1 native cells vs ZR75-1 25DOCR. F. ZR75-1 native cells vs ZR75-1 50DOCR.