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Figure 2 | BMC Cancer

Figure 2

From: Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance

Figure 2

Cell cycle analysis of native and resistant MDA-MB-231 and ZR75-1 by flow cytometry after synchronisation. The native and respective resistant cell lines were treated with 25nM or 50nM of paclitaxel. The DNA content was measured by flow cytometry to determine the distribution of cell in each phase. The histograms demonstrate the cell cycle distribution within the cell population. A MDA-MB-231 native and MDA-MB231 25PACR cells with or without 25nM paclitaxel. B MDA-MB-231 native and MDA-MB231 25PACR cells with or without 50nM paclitaxel. C ZR75-1 native and ZR75-1 25PACR cells with or without 25nM paclitaxel. D ZR75-1 native and ZR75-1 25PACR cells with or without 50nM paclitaxel. E ZR75-1 native and ZR75-1 25DOCR cells with or without 25nM docetaxel. F ZR75-1 native and ZR75-1 50DOCR cells with or without 50nM docetaxel. Standard deviation of three experiments are shown in brackets.

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