| (A) | (B) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
 | Patients included in the diplotype survival analyses |  | Stratified according to IL6 diplotype* | Patients included in the rs1800795 survival analyses |  | Stratified accoding to rs1800795** | |||||
 |  |  | GGGC/GGGC | AGCC/GGGC | AGCC/AGCC | Rare diplotypes |  |  | GG | GC | CC |
 | Median (IQR***) or n (%) | Missing | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR***) or n (%) | Missing | Median (IQR) or n (%) | Median (IQR) or n (%) | Median (IQR) or n (%) |
n= | 567 | Â | 130 (22.9) | 221 (39.0) | 131 (23.1) | 85 (15.0) | 574 | Â | 181 (31.5) | 257 (44.8) | 136 (23.7) |
Age at diagnosis, yrs | 59.7 (51.8-66.3) | - | 60.5 (49.2-66.7) | 59.5 (51.4-66.7) | 59.8 (53.8-66.4) | 58.4 (51.1-65.2) | 59.8 (52.0-66.4) | - | 60.5 (49.9-67.1) | 59.5 (52.2-66.4) | 59.8 (53.8-66.3) |
Weight, kgs | 68.0 (61.0-76.7) | 2 | 69.0 (62.0-81.3) | 67.0 (60.0-75.0) | 68.0 (61.0-78.5) | 68.3 (62.0-77.6) | 68.0 (61.0-76.9) | 2 | 69.0 (61.9-80.0) | 67.1 (60.4-75.0) | 69.0 (61.0-78.9) |
Height, m | 1.66 (1.62-1.70) | 1 | 1.66 (1.62-1.71) | 1.65 (1.62-1.69) | 1.65 (1.62-1.70) | 1.67 (1.60-1.70) | 1.66 (1.62-1.70) | 1 | 1.66 (1.60-1.71) | 1.66 (1.62-1.69) | 1.66 (1.62-1.70) |
BMI, kgs/m 2 | 24.6 (22.3-27.7) | 3 | 25.2 (22.9-29.1) | 24.3 (21.9-26.9) | 24.6 (22.4-28.6) | 24.4 (22.2-28.2) | 24.6 (22.3-27.9) | 3 | 25.2 (22.6-28.7) | 24.4 (22.1-27.4) | 24.6 (22.4-28.8) |
Breast volume | 1000 (600–1450) | 75a | 1000 (700–1538) | 950 (600–1450) | 988 (600–1450) | 900 (585–1563) | 1000 (600–1450) | 75a | 950 (650–1400) | 1000 (625–1563) | 1000 (600–1450) |
Breast volume ≥850 ml | 281 (57.1) | 75a | 68 (60.7) | 110 (55.6) | 65 (59.1) | 38 (52.8) | 286 (57.3) | 75a | 86 (55.8) | 132 (57.4) | 68 (59.1) |
Waist-Hip Ratio | 0.84 (0.78-0.89) | 2 | 0.84 (0.78-0.90) | 0.83 (0.78-0.88) | 0.84 (0.79-0.89) | 0.83 (0.78-0.89) | 0.84 (0.78-0.89) | 2 | 0.83 (0.78-0.90) | 0.83 (0.78-0.88) | 0.84 (0.79-0.89) |
Age at menarche, yrs | 13 (12–14) | 3 | 13 (12–14) | 13 (12–14) | 14 (13–14) | 13 (12–14) | 13 (12–14) | 3 | 13 (12–14) | 13 (12–14) | 14 (13–14) |
Parous | 485 (85.5) | - | 111 (85.4) | 192 (86.9) | 108 (82.4) | 74 (87.1) | 490 (85.4) | - | 156 (86.2) | 222 (86.4) | 112 (82.4) |
Alcohol use | Â | 1 | Â | Â | Â | Â | Â | 1 | Â | Â | Â |
Never | 62 (11.0) | Â | 19 (14.6) | 23 (10.4) | 15 (11.5) | 5 (6.0) | 62 (10.8) | Â | 23 (12.8) | 24 (9.3) | 15 (11.0) |
Not more than once a month | 149 (26.3) | Â | 37 (28.5) | 57 (25.8) | 34 (26.0) | 21 (25.0) | 154 (26.9) | Â | 48 (26.7) | 69 (26.8) | 37 (27.2) |
2-4 times per month | 216 (38.2) | Â | 41 (31.5) | 84 (38.0) | 54 (41.2) | 37 (44.0) | 217 (37.9) | Â | 64 (35.6) | 97 (37.7) | 56 (41.2) |
2-3 times per week | 110 (19.4) | Â | 27 (20.8) | 51 (23.1) | 19 (14.5) | 13 (15.5) | 111 (19.4) | Â | 34 (18.9) | 58 (22.6) | 19 (14.0) |
4 or more times per week | 29 (5.1) | Â | 6 (4.6) | 6 (2.7) | 9 (6.9) | 8 (9.5) | 29 (5.1) | Â | 11 (6.1) | 9 (3.5) | 9 (6.6) |
Pre-operative smoker | 121 (21.3) | - | 22 (16.9) | 48 (21.7) | 30 (22.9) | 21 (24.7) | 121 (21.1) | - | 33 (18.2) | 57 (22.2) | 31 (22.8) |
Smoker at any visit | 129 (22.8) | - | 23 (17.7) | 51 (23.1) | 32 (24.4) | 23 (27.1) | 130 (22.6) | - | 36 (19.9) | 60 (23.3) | 34 (25.0) |
Pre-operative use of antidepressants | 56 (9.9) | - | 14 (10.8) | 21 (9.5) | 16 (12.2) | 5 (5.9) | 57 (9.9) | - | 18 (9.9) | 23 (8.9) | 16 (11.8) |
Ever use of HRT, % | 263 (46.5) | 1 | 54 (41.9) | 102 (46.2) | 70 (53.4) | 37 (43.5) | 267 (46.6) | 1 | 77 (42.8) | 118 (45.9) | 72 (52.9) |
Screening detected tumor | 289 (60.3) | 88b | 59 (56.7) | 102 (54.8) | 78 (68.4) | 50 (66.7) | 293 (60.5) | 90b | 84 (56.8) | 129 (59.2) | 80 (67.8) |